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Depression in Youth Onset Type 2 Diabetes
The main purpose of this study is to compare a group-based interpersonal psychotherapy (IPT) program and a Type 2 Diabetes education program to determine if th…
M-O-M-S on the Bayou: Implementation of an Intervention for Mental Health in Pregnancy
Disasters have negative effects in the short term (physical trauma, adverse environmental exposures, and unstable housing) and the long term (relocation, chang…
An Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
Background: Major depressive disorder (MDD) is a serious mental illness that can put people at risk of self-harm and death. Many drugs are used to treat MDD, …
Be Well at Work-Plus: A Depression and Physical Activity Intervention for Hospital Service Workers (Aim 3).
This small randomized controlled trial will evaluate a workplace-based depression intervention that is tailored to the specific social and behavioral needs of …
The Impact of Mindfulness and Meditation Based Lactation Education on Maternal Breastmilk in the Neonatal ICU: Intervention Study
The purpose of this research is to investigate associations between mindfulness and meditation techniques and changes in maternal breastmilk in the mother pump…
Multi-site Randomized Controlled Trial Comparing the Efficacy of Behavioral Approaches to Improve Mood and Sleep in Adults
This is a multi-site randomized control trial involving people age 55+ years who have current depression symptoms plus another suicide risk indicator (either c…
Optimizing Digital Behavioral Treatment for Co-occurring Insomnia and Depression
This study has two primary objectives, each of which addresses critical clinical and research gaps for individuals who have co-occurring insomnia and depressio…
Stratified Pharmacological Approaches for Regulating Circuit-Level Effects Study
This research study aims to understand how people with depression respond to the medication pramipexole and to determine whether clinical response differs depe…
Tracking Brain Imaging Changes in Depression Over Clinical Accelerated Transcranial Magnetic Stimulation (TMS) Therapy at the Individual Level
This study aims to investigate whether phenotypic-related brain states revealed by a novel INSCAPE ("Individualized Network-based Single-frame Coactivation Pat…
Modulating Spinal Interoceptive Pathways to Evaluate Their Role and Therapeutic Potential in MDD Symptomatic Domains
Spinal interoceptive pathways (SIPs) convey bodily signals to an interoceptive system in the brain and their dysregulation is linked to major depressive disord…
Understanding the Role of Doulas in Supporting People With PMADs
Detailed Description The doula-led intervention developed during the first phase of this project will be pilot tested for feasibility. Following the recruitmen…
Treatment Research Investigating Depression Effects on Neuroimmune Targets (TRIDENT)
The purpose of this randomized controlled trial is to understand how a cognitive-behavioral treatment (a form of psychological treatment) for depression change…