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Deep Brain Stimulation (DBS) for Depression Using Directional Current Steering and Individualized Network Targeting
The goal of the study is to address the unmet need of TRD patients by identifying brain networks critical for treating depression and to use next generation pr…
Mindful Self-Compassion for Anxiety and Depression: A Randomized Comparison of In-Person Versus Videoconference Delivery
The study will compare the delivery of an 8-week Mindful Self-Compassion training, in-person against video-conference, on anxiety and depression symptom severi…
AMP-C: A Digital Therapeutic for Reward Dysfunction in Co-Occurring Depression and Cannabis Use
The purpose of this study is to examine the feasibility, acceptability, and preliminary efficacy of a digital intervention for co-occurring cannabis use and de…
Investigation of Sensory Synchronized Human Brain Imaging and Neuromodulation
The purpose of this research study is to better understand the relationship between the type of brain stimulation used and how it changes brain activity in adu…
Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression
The study will consist of a 24-week-long trial examining outcomes in patients with Major Depressive Disorder and suicidal ideation who will receive intravenous…
Improving Outcomes in Adolescent Inpatient Depression With Deep Transcranial Magnetic Stimulation
Evaluate the feasibility, safety, and preliminary efficacy of deep Transcranial Magnetic Stimulation (dTMS) as an adjunctive treatment for adolescents hospital…
Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression - R33
The purpose of this research study is to determine if application of near infrared energy to the forehead can change blood flow in the brains of people with de…
Beyond the Clinic: Enhancing Depression Surveillance With a Digital Biomarker
Researchers hope to see if the data smartphones collect continuously can be used to predict if patient's depression symptoms will return. They will do this by …
Evaluation of the Antidepressant Effects of Nitrous Oxide in People With Major Depressive Disorder
To evaluate the acute and sustained antidepressant effects of nitrous oxide in people with major depressive disorder; and further evaluate these effects by ide…
A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder
The goal of this clinical trial is to learn if ABX-002 added to an existing antidepressant treatment will benefit depression symptoms in adults with moderate t…
Efficacy of Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy in Remission of Suicidal Ideation
This protocol proposes an initial randomized clinical trial that includes all patients with suicidal ideation (SI) at baseline, and with SI as the primary outc…
Nicotinic Modulation of the Cognitive Control System in Late-Life Depression (R33 Phase)
Deficits in cognitive control are core features of late-life depression (LLD), contributing both to emotion dysregulation and problems with inhibiting irreleva…