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2,801 recruiting studies matching your filters

A Phase 1/2, Open-label, Multi-national, Multiple-cohort, Dose-escalation Study to Evaluate the Safety, Tolerability, and Efficacy of HG004 Gene Therapy in Subjects with RPE65-associated Leber Congenital Amaurosis Type 2 (LCA2)

The purpose of the study is to determine whether HG004 as gene therapy is safe and effective for the treatment of Leber Congenital Amaurosis caused by mutation…

Leber Congenital AmaurosisInherited Retinal Diseases Caused by RPE65 Mutations

Estimated

~$10 – $8,750

HuidaGene Therapeutics Co., Ltd.NCT05906953

Observational

A Randomized, Sham-controlled Pilot Trial of a Novel Therapeutic Strategy (taVNS) for Autonomic Nervous System (ANS) Dysfunction in Chronic Kidney Disease (CKD)

30 patients will participate in a prospective randomized clinical trial to test the safety, tolerability and efficacy of transcutaneous auricular vagus nerve s…

Chronic Kidney Diseases

Estimated

~$10 – $7,500

NYU Langone HealthNCT06927024

Eosinophils and Inflammation, an Expanded Study

The purpose of this study is to elucidate the mechanisms underlying eosinophil growth, survival, migration, and function and to investigate and further charact…

Eosinophilic Gastrointestinal Disease Eosinophilic Inflammatory DiseaseFood Allergy

Estimated

~$10 – $675

Children's Hospital Medical Center, CincinnatiNCT00267501

Phase 2

A 4-Week, Randomized, Double-Masked, Parallel-Group, Active-Controlled, Multicenter Study Evaluating Lifitegrast/Perfluorohexyloctane Fixed-Dose Combination Administered Twice Daily on Signs and Symptoms of Dry Eye Disease

A 4-Week, Randomized, Double-Masked, Parallel-Group, Active-Controlled, Multicenter Study Evaluating Lifitegrast/Perfluorohexyloctane Fixed-Dose Combination Ad…

Dry Eye Disease

Estimated

~$10 – $8,750

Bausch & Lomb IncorporatedNCT07128628

Tulane Abdominal Transplant Institute (TATI) of Solid Organ Transplantation of HIV-Positive Recipients From HIV-Positive Donors (TATI HOPE Act)

The U.S. Department of Health and Human Services (HHS), through the National Institutes of Health (NIH), published Final Human Immunodeficiency Virus (HIV) Org…

Human Immunodeficiency VirusEnd Stage Renal Disease

Estimated

~$10 – $750

Tulane UniversityNCT05159466

Phase 1

Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?

Obstructive sleep apnea (OSA) is common in older adults and has recently been implicated in pathogenesis of Alzheimer's disease (AD). Research has shown that s…

OSASleep ApneaObstructive Sleep Apnea+1 more

Estimated

~$10 – $6,250

University of California, San DiegoNCT05094271

Observational

Mindfulness-Based Intervention for Pain and Sleep in Adolescents and Young Adults With Sickle Cell Disease

This study examines the feasibility and acceptability of a mindfulness-based mobile intervention designed to support pain and sleep management among adolescent…

Chronic PainSickle Cell DiseaseSleep Disturbance

Estimated

~$10 – $6,250

University of Illinois at ChicagoNCT07402811

Pounce™ Thrombectomy System Retrospective Registry

The PROWL registry is an open-label retrospective, multi-center, US study of the Surmodics™ Pounce™ Thrombectomy System for the non-surgical removal of emboli …

Peripheral Arterial DiseaseAcute Limb Ischemia

Estimated

~$10 – $1,050

SurModics, Inc.NCT05868161

Clinical Outcomes of Medications Post Anti-TNF: Researching Effectiveness in Pediatric IBD

The purpose of the study is to compare the clinical effectiveness and safety of newer inflammatory bowel disease (IBD) medications in anti-tumor necrosis facto…

Ulcerative Colitis, PediatricInflammatory Bowel DiseasesCrohn Disease

Estimated

~$10 – $750

University of North Carolina, Chapel HillNCT07198113

Prospective Validation of the Novel PVD-B65 Risk Score in Patients With Chronic Lung Disease and Pulmonary Hypertension

Prospective observational study to determine if the PVD-B65 risk score for one-year mortality in patients with chronic lung disease and pulmonary hypertension …

Chronic Lung DiseasePulmonary Hypertension

Estimated

~$10 – $750

Temple UniversityNCT07151768

Multi-Center Registry Comparing Stent and Non-Stent Based Interventional Outcomes for Patients With Peripheral Arterial Disease

XLPAD is an observational study designed to evaluate the effectiveness and use of stent and non-stent based therapies among PAD patients. The study will create…

Peripheral Arterial Disease

Estimated

~$10 – $1,125

Baylor Research InstituteNCT01904851

Phase 2

Phase 2 Study of Ruxolitinib-Based Primary Treatment for Acute GVHD

This clinical trial will study ruxolitinib-based treatment of acute graft-versus-host-disease (GVHD) that developed following allogeneic hematopoietic cell tra…

Acute Graft-versus-host DiseaseAllogeneic Bone Marrow TransplantationAdverse Effects

Estimated

~$10 – $7,500

John LevineNCT06936566