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2,803 recruiting studies matching your filters

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Effect of Muvalaplin on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) Who Have Had a Prior Atherosclerotic Cardiovascular Event or Are at Risk for a First Atherosclerotic Cardiovascular Event

The purpose of this study is to evaluate the efficacy of muvalaplin in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovas…

Elevated Lp(a)Atherosclerotic Cardiovascular Disease (ASCVD)

Estimated

~$10 – $7,500

Eli Lilly and CompanyNCT07157774

Phase 1

2-Hydroxybenzylamine (2-HOBA) Phase 1b/2a Proof-of Concept, Dose-Finding, Biomarker Study in Early Alzheimer's Patients

Investigators propose a phase 1b/2a, randomized, double-blind, placebo-controlled, parallel group dose finding and biomarker study to evaluate the safety, tole…

Alzheimer DiseaseMild Cognitive Impairment

Estimated

~$10 – $8,750

MTI Biotech IncNCT06432166

Phase 2

A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study of VERVE-102, a One-Time Dose Gene Editing Medicine, in Adults With or at High Risk for Atherosclerotic Cardiovascular Disease (ASCVD) Who Require Additional Low-Density Lipoprotein-Cholesterol (LDL-C) Lowering

The purpose of this study is to measure the change in bad cholesterol (LDL-C) with VERVE-102 compared to placebo in adults who have plaque buildup in their art…

AtherosclerosisCardiovascular DiseaseHypercholesterolemia

Estimated

~$10 – $8,750

Verve Therapeutics, Inc.NCT07839936

Studies of the Natural History, Pathogenesis and Outcome of Ocular Disorders

Background: The National Eye Institute (NEI) wants to evaluate and provide standard treatment to people with eye diseases. Objective: To examine and treat p…

Eye Disease

Estimated

~$10 – $675

National Eye Institute (NEI)NCT02821767

Observational

Targeting Gut Inflammation Through Diet: a Tailored American Diet for Patients With Crohn's Disease

The purpose of this study is to test the effect of an anti-inflammatory diet tailored for patients living in the United States with Crohn's Disease (CD) on cli…

Crohn's Disease, ActiveCrohn's Disease (CD)Diet Interventions

Estimated

~$10 – $6,250

University of MiamiNCT07671872

Phase 3

An 18-month, Open-label, Single-arm Safety Extension Study of an age-and Bodyweight-adjusted Oral Finerenone Regimen, in Addition to an ACEI or ARB, for the Treatment of Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria

Researchers are looking for a better way to treat children who have chronic kidney disease (CKD), which is long-term kidney disease, and proteinuria, a conditi…

Chronic Kidney DiseaseProteinuriaChildren

Estimated

~$10 – $7,500

BayerNCT05457283

Intravascular Ultrasound Guidance for Complex High-risk Indicated Procedures in Underrepresented Patient Populations Registry

The IVUS CHIP UPP Registry is a prospective, observational, multicenter, single-arm registry. A total of 1010 patients with complex coronary lesions will be en…

Coronary Artery DiseaseCoronary Artery Disease Risk HighComplex Coronary Artery Disease

A Randomized Controlled Pilot Study of Two Doses of Cord Blood Tissue-Derived Mesenchymal Stromal Cells Combined With Ruxolitinib Versus Ruxolitinib Alone for Therapy of Steroid-Refractory Acute Graft Versus Host Disease

This early phase I trial is to find out the effect of adding cord blood tissue-derived mesenchymal stromal cells (cb-MSCs) to ruxolitinib in treating patients …

Hematopoietic and Lymphoid Cell NeoplasmSteroid Refractory Graft Versus Host Disease

Estimated

~$10 – $6,250

M.D. Anderson Cancer CenterNCT04744116

Phase 3

A Multicenter, Open-label, Phase 3 Extension Study to Evaluate the Long-term Efficacy and Safety in Participants Who Are Currently on Treatment in a Belzutifan Study (LITESPARK-043)

Researchers are looking for new ways to treat advanced solid tumors and von Hippel-Lindau (VHL)-related tumors: * Advanced means the cancer has spread to othe…

Von Hippel-Lindau DiseaseMalignant Neoplasms

Estimated

~$10 – $8,750

Merck Sharp & Dohme LLCNCT07405164

Phase 3

A Multicenter, Multinational, Randomized, Double-blind, Placebo-controlled Phase 3, Induction Study to Evaluate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease

This is a multinational, multicenter, randomized, double-blind, placebo-controlled, Phase 3 induction study, comprised of 3 sub-studies, to evaluate the effica…

A Phase 1b Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DISC-3405 in Participants With Sickle Cell Disease

This is an open-label, multicenter, within-participant dose-escalation study examining up to 3 dose levels of DISC-3405 and will assess the safety, tolerabilit…

Sickle Cell Disease

Estimated

~$10 – $8,750

Disc Medicine, IncNCT07187973

The American Lung Association (ALA) Lung Health Cohort

The ALA-LHC is a longitudinal, multi-center cohort study that will enroll approximately 4,000 young adults between the ages of 25-35 who do not have severe lun…

Lung Diseases

Estimated

~$10 – $750

Johns Hopkins UniversityNCT04543461