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Yale UniversityNCT07219992

Phase 4

Suvorexant: A Dual Orexin Receptor Antagonist for Treating Sleep Disturbance inPosttraumatic Stress

Post-traumatic stress disorder (PTSD) is a common consequence of combat that can result in trauma-related hyperarousal and sleep disturbances. Poor sleep, one …

Sleep Initiation and Maintenance DisordersStress Disorders, Posttraumatic

VA Office of Research and DevelopmentNCT03642028

~$10 – $5,625

Phase 2

129 Xenon MRI as a Biomarker for Diagnosis and Response to Therapy in Pulmonary Arterial Hypertension (PAH)

The overall study objectives outlined in this study are to derive 129Xe MRI pulmonary vascular biomarker signatures that differentiate common subtypes of PAH a…

Pulmonary Arterial HypertensionIdiopathic Pulmonary Arterial HypertensionPulmonary Arterial Hypertension Associated With Connective Tissue Disease (Disorder)+1 more

Bastiaan DriehuysNCT06104228

~$10 – $7,500

Phase 2

Examining the Effects of Cytisinicline on Neural Substrates of Cigarette Cue-Reactivity

This study will randomize 64 non-treatment seeking individuals who smoke cigarettes daily in a double-blind, placebo-controlled laboratory study testing the ef…

Smoking CessationTobacco Use Disorder

University of California, Los AngelesNCT06617312

Evaluation of a Peer Recovery Support Program Adapted to Target Retention in Clinic-based Medication for Opioid Use Disorder Treatment

The goal of this clinical trial is to learn if receiving peer recovery support (support services provided by trained "peers" with lived experience of addiction…

Opioid Use Disorder

Geisinger ClinicNCT07197801

Spermatogenesis and Semen DisordersInfertility, Male

The Impact of Power Prenatal Supplements for Males on YO Score At-home Sperm Test Results Over a Three Month Course

Male factor infertility is a leading cause of primary and secondary infertility. Poor sperm quality is defined as having an abnormal semen analysis. There are…

The Bird and Be Co IncNCT05951075

~$10 – $8,750

Alcohol UseAdolescentMild Alcohol Use Disorder+1 more

Evaluating Caregiver Involvement in Primary Care-Based Brief Interventions for Adolescent Alcohol Use Problems

Intervention for mild severity alcohol use among U.S. teens is crucial, as alcohol is the most commonly used substance in this age group, yet few receive the n…

Indiana UniversityNCT06593652

Phase 1

A Phase I/II Single and Multiple Dose Tolerability, Safety and Pharmacokinetic Study of CMND-100 in Healthy Volunteers and Subjects With Alcohol Use Disorder (AUD)

The primary objective of this study is to find the tolerable dose and characterize the safety and pharmacokinetics/ pharmacodynamics (PK/PD) of single and repe…

Alcohol Use Disorder

Clearmind Medicine Inc.NCT05913752

~$10 – $8,750

Sensorimotor and Psychosocial Trajectories in Adolescents With Tic Disorder

Individuals with tic disorders have lower quality of life, sensory and movement difficulties, and poorer mental, social, and physical health compared to the ge…

Tourette SyndromeTic Disorder

Vanderbilt University Medical CenterNCT06576726

~$10 – $750

Development of a Database to Investigate Digital and Blood-Based Biomarkers and Their Relationship to Tau and Amyloid PET Imaging in Older Participants Who Are Cognitively Normal (CN), Have Mild Cognitive Impairment (MCI), or Have Mild-to-Moderate AD Dementia

Bio-Hermes-002 is a 120-day cross-sectional study that will result in a blood, CSF, retinal, digital, MRI, and PET brain imaging biomarker database that can be…

Mild Cognitive ImpairmentAlzheimer's DiseaseAlzheimer's Disease, Early Onset+3 more

GAP Innovations, PBCNCT06584357

~$10 – $1,125

SchizophreniaSchizoaffective Disorder

Accelerated Neuromodulation of Prefrontal Circuitry During Clozapine Treatment

In this study, the investigators will examine whether a type of repetitive transcranial magnetic stimulation called accelerated intermittent theta burst stimul…

Deepak K. Sarpal, M.D.NCT06003036

~$10 – $7,500

Eating DisordersAnorexia NervosaBulimia Nervosa+1 more

Developing an Artificial Intelligence (AI)-Powered Exposure Therapy Chatbot for Adolescents and Young Adults With Eating Disorders

The goal of this study is to develop and refine an artificial intelligence (AI)-powered Exposure Therapy for Eating Disorders chatbot web-app that effectively …