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Development and Validation of a Measure of Substance-Related Consequences: A Novel Clinical Outcome Assessment for Substance Use Disorder Trials
The goal of this study is to develop a new tool for measuring substance use disorder treatment outcome. We will start by interviewing people and gathering advi…
A Phase 1, Single-Center, Double-Blind, Randomized, Placebo-Controlled Study to Explore the Effect of SP-624 on Brain Network Analytics in Cohorts of Healthy Adult Subjects and Subjects With Major Depressive Disorder
The main goal of this clinical trial is to learn if the active study drug (code name: SP-624) has any effect on the electrical activity of the brain in adult h…
Cannabidiol-Enhanced Cognitive Behavioral Therapy for Generalized Anxiety Disorder
This randomized, double-blind, placebo-controlled clinical trial investigates the use of Food and Drug Administration (FDA)-approved cannabidiol (EPIDIOLEX®) a…
Deep Brain Stimulation (DBS) for Depression Using Directional Current Steering and Individualized Network Targeting
The goal of the study is to address the unmet need of TRD patients by identifying brain networks critical for treating depression and to use next generation pr…
Developing a Clinical Outcome Assessment for Opioid Craving
The purpose of this study is to collect information about opioid craving so that the investigators can develop an opioid craving assessment to improve treatmen…
Investigating Changes in Premonitory Urges During Habit Reversal Training
The primary aim of this study is to learn more about premonitory urges (PU) when using Habit Reversal Training (HRT) to treat tics. The main focus of this stu…
Examining Appeal and Addiction Potential of Novel E-cigarette Constituents Among Adults
This study is an examination of the influence of cooling components of WS-3, WS-23, and menthol on the appeal and addiction potential of nicotine-containing e-…
Deep TMS Neuromodulation of Neural Circuits Associated With Stimulant Use Disorder
This study aims to evaluate the efficacy of deep transcranial magnetic stimulation (dTMS) as a treatment for Veterans with a methamphetamine use disorder (MUD).
A Multisited Efficacy Trial of Veteran Voices and Visions
Veterans with schizophrenia spectrum disorders who experience psychosis struggle with social integration- e.g., participation in work, housing, and citizenship…
Brain Metabolism Observed at 7 Tesla in Health and Metabolic Disease.
The goal is to develop methodology to monitor flux in the citric acid cycle in brain via 13C nuclear magnetic resonance (NMR) spectroscopy at 7 Tesla.
Mindful Self-Compassion for Anxiety and Depression: A Randomized Comparison of In-Person Versus Videoconference Delivery
The study will compare the delivery of an 8-week Mindful Self-Compassion training, in-person against video-conference, on anxiety and depression symptom severi…
Retrieval-based Word Learning in Developmental Language Disorder: Adaptive Retrieval Schedule
Children with developmental language disorder (DLD; also referred to as specific language impairment) experience a significant deficit in language ability that…