Find your next paid study

University of Nevada, Las VegasNCT07630207

~$10 – $750

Down SyndromeObstructive Sleep Apnea

Randomized Control Trial of Oxygen Therapy in Children and Adolescents With Down Syndrome and Obstructive Sleep Apnea

The purpose of this study is to assess whether oxygen supplementation during sleep improves working memory and other clinical and patient-reported outcomes amo…

Brigham and Women's HospitalNCT06043440

Phase 3

Dysautonomia InVestigation in Individuals With Down SyndromE: DIVE Study

Down syndrome (DS), the most common genetic cause of intellectual disability, is associated with widespread organ dysfunction, including abnormalities in the a…

Down SyndromeAutonomic Dysfunction

University of Colorado, DenverNCT07238465

Down Syndrome Regression Disorder (DSRD)Down Syndrome (Trisomy 21)Neuroinflammatory / Neuropsychiatric Disorder

An Open-Label Phase II Feasibility Study for the Use of Ublituximab in Adults With Down Syndrome Regression Disorder

The goal of this clinical trial is to evaluate whether the monoclonal antibody ublituximab can treat Down Syndrome Regression Disorder (DSRD) by assessing its …

Jonathan SantoroNCT07812181

~$10 – $7,500

Phase 1

Phase 1B Trial on Escalating Doses of Memantine in Down Syndrome

Down syndrome (DS) is typically caused by an extra chromosome 21 in the cell nucleus (trisomy 21, or T21). T21 is both the most common cause of genetically def…

Down SyndromeIntellectual DisabilityAlzheimer Dementia (AD)

University Hospitals Cleveland Medical CenterNCT07531940

Observational

Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS)

The overall objective of this randomized clinical trial is to test the effectiveness of a personalized approach to the surgical treatment of OSA in children wi…

Obstructive Sleep ApneaDown Syndrome

Oregon Health and Science UniversityNCT05508971

Collection of Whole Blood Specimens From Pregnant Women at Increased Risk of Fetal Chromosomal Abnormality for Use in Development of a Noninvasive Prenatal Test in the Detection of the Relative Quantity of Chromosomal Material in Circulating Cell-Free DNA Extracted From Maternal Plasma

The specimen collection is designed for the purpose of the development of a noninvasive prenatal test for T21.

Down SyndromeFetal Aneuploidy

Sequenom, Inc.NCT01429389

~$10 – $1,050

Down Syndrome-Associated Alzheimer's Disease (DS-AD)

A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study, to Evaluate Efficacy, Safety, Tolerability, and Pharmacodynamics of Intrathecally Administered Mivelsiran in Adult Participants With Early-Stage Down Syndrome-Associated Alzheimer's Disease (DS-AD)

The purpose of the study is to evaluate the effect of mivelsiran in adult participants with early-stage DS-AD and to characterize the safety, tolerability, and…

Alnylam PharmaceuticalsNCT07636811

~$10 – $8,750

Phase 4

Endotype DIrected Treatment for OSA in Down Syndrome

Down syndrome is the most common genetic cause of intellectual disability. People with Down syndrome often have obstructive sleep apnea (OSA), a condition wher…

Obstructive Sleep Apnea (OSA)Down Syndrome

University of ArizonaNCT07280468

Modulation of the Immune System in Down Syndrome for Improved Outcomes and Neurodevelopment - 1

This protocol describes a phase 2, double-blind, randomized, placebo-controlled clinical trial for Janus kinase (JAK) inhibition in Down syndrome (DS). This tr…

Down Syndrome

University of Colorado, DenverNCT07598643

Down SyndromeRecurrent B Acute Lymphoblastic Leukemia

A Phase 2 Study of Blinatumomab (NSC# 765986) in Combination With Nivolumab (NSC# 748726), a Checkpoint Inhibitor of PD-1, in B-ALL Patients Aged >/= 1 to < 31 Years Old With First Relapse

This phase II trial studies the effect of nivolumab in combination with blinatumomab compared to blinatumomab alone in treating patients with B-cell acute lymp…

National Cancer Institute (NCI)NCT04546399

~$10 – $5,625

Observational

Executive Function Intervention for Young Children With Down Syndrome

The Executive Function Play Opportunities (EXPO) study is a sequential, multiple assignment, randomized trial (SMART) evaluating adaptive caregiver-mediated in…

Down SyndromeTrisomy 21