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231 recruiting studies matching your filters

A Pilot Study to Determine the Safety and Efficacy of Incorporating Hyperbaric Oxygen Therapy Into RIC Fludarabine and Melphalan and Allogeneic Hematopoietic Stem/Progenitor Transplantation

The purpose of this study is to determine if hyperbaric oxygen therapy is safe in the setting of stem cell transplantation. This study will also determine if h…

Acute Myeloid LeukemiaMyelodysplastic SyndromesChronic Myelomonocytic Leukemia+4 more

Estimated

~$10 – $7,500

Omar AljitawiNCT03964506

Phase 4

Estrogen Supplementation and Bone Health in Women With CF (STURDY)

The goal of this study is to learn about the role of estrogen and other hormones in bone development in adolescent and young adult women with cystic fibrosis (…

Cystic FibrosisHypoestrogenism

Estimated

~$10 – $6,250

Johns Hopkins UniversityNCT05704036

Phase 2

A Phase IIa, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of INS018_055 Administered Orally to Subjects With Idiopathic Pulmonary Fibrosis (IPF)

The purpose of this revised Phase IIa study is to demonstrate safety of INS018\_055 over 12 weeks in adults with Idiopathic Pulmonary Fibrosis (IPF).

Idiopathic Pulmonary Fibrosis (IPF)

Estimated

~$10 – $8,750

InSilico Medicine Hong Kong LimitedNCT05975983

Observational

Comparing High Intensity Stretch Device Combined With Physical Therapy Versus Physical Therapy Alone to Prevent Motion-Restoring Surgery Following Primary Total Knee Arthroplasty: Study Protocol for a Randomized Controlled Trial

The goal of this clinical trial is to learn whether adding a stretching device to standard physical therapy can help people regain knee bending after total kne…

Joint ContracturesTotal Knee AnthroplastyKnee Arthrofibrosis

Estimated

~$10 – $8,750

Ermi LLCNCT07454356

Prospective Assessment of Allogeneic Hematopoietic Cell Transplantation in Patients With Myelofibrosis

This observational study will compare outcomes of a prospectively-enrolled cohort of Hematopoietic Stem Cell Transplant (HCT) recipients with outcomes of a coh…

Myelofibrosis

Estimated

~$10 – $1,125

Center for International Blood and Marrow Transplant ResearchNCT02934477

Phase 2

Maralixibat in Patients With Cystic Fibrosis and Constipation, A Within-Subjects Pilot Study

Chronic constipation is common in children with cystic fibrosis (CF), likely due to impaired chloride channel function that reduces intestinal secretions. Stan…

Constipation Chronic IdiopathicCystic Fibrosis

Estimated

~$10 – $6,250

Children's Hospital Los AngelesNCT06413368

Phase 1

A Phase 1 Study of EP31670, a Dual BET and CBP/p300 Inhibitor in Patients With Targeted Advanced Solid Tumors and Hematological Malignancies

A Phase 1, first-in-human study of EP31670, a dual BET and CBP/p300 inhibitor in patients with targeted advanced solid tumors and Hematological Malignancies

Castrate Resistant Prostate CancerNUT CarcinomaChronic Myelomonocytic Leukemia+1 more

Estimated

~$10 – $8,750

Epigenetix, Inc.NCT05488548

Observational

CGM Dynamic Index (CDI) for Predicting Prediabetes in People With Cystic Fibrosis

The primary objective of this pilot study is to develop a CGM-based model to predict the progression from prediabetes to diabetes in individuals with cystic fi…

PrediabetesCystic Fibrosis (CF)Cystic Fibrosis-related Diabetes

Estimated

~$10 – $6,250

Indiana UniversityNCT06642610

Phase 1

Treating Anemia in Myelofibrosis With Repurposed Drugs (Nelfinavir) That Restore Iron Delivery to the Bone Marrow

This is a phase I/II protocol investigating whether Nelfinavir can improve anemia and lower serum fibrosis biomarkers in Myelofibrosis patients.

MyelofibrosisMyelofibrosis; Anemia

Estimated

~$10 – $6,250

University of California, IrvineNCT07281781

Phase 3

Sinonasal Therapies and Histologic Correlations for Patients With Cystic Fibrosis in the Era of Highly Effective Modulator Therapy

The investigators are doing this study to discover if it is appropriate for people with Cystic Fibrosis (CF) on highly effective modulator therapy (HEMT) to st…

Cystic Fibrosis (CF)Chronic Rhinosinusitis (CRS)

Estimated

~$10 – $6,250

Indiana UniversityNCT06996951

Phase 1

Phase I Study Accessing the Safety of Pacritinib in Combination With Talazoparib in Patients With Myeloproliferative Neoplasms Unresponsive to Frontline JAK2 (Janus Kinase 2) Inhibition

This is a prospective phase I dose-escalation study, with the primary objective to access the MTD and find the RP2D of talazoparib, given in combination with s…

Primary MyelofibrosisPost-polycythemia Vera MyelofibrosisPost-essential Thrombocythemia Myelofibrosis+3 more

Estimated

~$10 – $6,250

Fox Chase Cancer CenterNCT06218628

Phase 2

Losartan for Diffuse Myocardial Fibrosis in Sickle Cell Disease: A Prospective, Phase II Study.

This study is a pilot, phase II, open-label study of the angiotensin II receptor blocker, losartan, in patients with Sickle Cell Disease (SCD) 6 years or older…

Sickle Cell DiseaseDiffuse Myocardial Fibrosis

Estimated

~$10 – $5,625

Children's Hospital Medical Center, CincinnatiNCT05012631