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Phase 1
The Development of Minimally Invasive Nanosensor Technology to Quantify Mitochondrial Function in Human Muscle
Past mitochondrial disease treatment studies have been unsuccessful in determining treatment efficacy, and a major factor has been the lack of validated biomar…
Mitochondrial MyopathiesMitochondrial Diseases
Children's Hospital of PhiladelphiaNCT04086329
Phase 2
Tailored Exercise Training Study Among Adults With HFpEF
Heart failure with preserved ejection fraction (HFpEF) is associated with a high morbidity and mortality burden. There are limited pharmacological options avai…
HFpEF - Heart Failure With Preserved Ejection FractionDiabetic Cardiomyopathies
University of Texas Southwestern Medical CenterNCT07223242
Observational
Optimizing Beta Blocker Dosage in Women While Using the Wearable Cardioverter Defibrillator
The primary objective of this pilot study is to document the percentage achievement in effective HR control (average nighttime HR \< 70 bpm) during WCD use in …
CardiomyopathiesHeart Failure
Zoll Medical CorporationNCT04504188
A Patient Registry and Natural History Study of Patients with Biallelic HPDL Mutations
This study uses medical records that allow retrospective data extraction of clinical manifestation to assess the natural history of HPDL mutations
Mitochondrial EncephalomyopathiesHereditary Spastic ParaplegiaSpastic Paraplegia+4 more
University of California, San DiegoNCT05848271