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312 recruiting studies matching your filters

Assessing Pulmonary Changes in Hematopoietic Stem-Cell Transplantation Patients and Patients With Rare-Lung Diseases Using Hyperpolarized Xe MR Lung Imaging

This will be an un-blinded, open-label study of children and adults, including those who are being evaluated for or who have undergone HSCT, those with existin…

HSCTRespiratoryGas Exchange Impairment

Estimated

~$10 – $5,625

Children's Hospital Medical Center, CincinnatiNCT07823036

Observational

A Gait and Path Tortuosity System for Monitoring Cognitive Decline in Individuals at Risk for Alzheimer's Disease and/or Alzheimer's Disease Related Dementias (AD/ADRD)

This study tests an innovative system and service for collecting objective, consistent, and in-community gait parameters suitable for use as AD/ADRD biomarkers…

Mild Cognitive Impairment (MCI)Dementia

Estimated

~$10 – $7,500

HealthPartners InstituteNCT07127133

Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY

The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patien…

Ischemic StrokeIntracerebral HemorrhageSubarachnoid Hemorrhage+3 more

Estimated

~$10 – $750

Massachusetts General HospitalNCT04916210

Phase 1

A Phase 1, Open-Label Extension Groups Study in Subjects Having Hepatic Impairment With Cirrhosis Due to Cholestatic Liver Disease

A Phase 1, Open-label Extension Groups Study in Subjects having Hepatic Impairment with Cirrhosis due to Cholestatic Liver Disease

Hepatic ImpairmentCirrhosisCholestatic Liver Disease

Estimated

~$10 – $8,750

Zydus Therapeutics Inc.NCT05045482

Blood Amyloid, Tau, and Neurodegeneration Biomarkers and Prediction of Clinical Onset, Cognitive Decline, and Dementia Diagnosis

The purpose of this study is to determine the relationships between amyloid, tau, and neurodegeneration biomarkers in the blood and the presence of Alzheimer's…

Alzheimer DiseaseMild Cognitive ImpairmentDementia

Estimated

~$10 – $750

Washington University School of MedicineNCT06547099

Phase 1

A Two-part, Non-randomized, Open-label, Parallel-group Study to Assess the Effect of Renal Impairment on the Pharmacokinetics and Safety of RO7795081 Following a Single Oral Dose of RO7795081

The purpose of this study is to assess the effect of renal impairment on the pharmacokinetics (PK) and safety of RO7795081, following a single oral dose in par…

Renal Impairment

Estimated

~$10 – $7,500

Hoffmann-La RocheNCT07741604

Phase 1

An Open-label, Phase 1 Trial to Evaluate the Pharmacokinetics and Safety of a Single Dose of 80 μg Treprostinil Palmitil Inhalation Powder in Participants With Normal Hepatic Function and Participants With Hepatic Impairment

The primary purpose of the study is to determine the effect of mild, moderate, and severe hepatic impairment on the PK of total treprostinil palmitil (TP) and …

Hepatic Impairment

Estimated

~$10 – $8,750

Insmed IncorporatedNCT07643155

Observational

Designing a Spatial Navigation Intervention Protocol Informed by Region-specific Brain Activation for Mild Cognitive Impairment

The goal of this one-arm clinical trial is to determine whether participants with mild cognitive impairment (MCI) can successfully navigate a virtual reality (…

Mild Cognitive Impairment (MCI)

Estimated

~$10 – $6,250

Albert Einstein College of MedicineNCT07225400

Sinus Disease in Young Children With Cystic Fibrosis

This is a prospective, observational study examining the impact of highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulators on ch…

Cystic Fibrosis in ChildrenCystic FibrosisChronic Rhinosinusitis (Diagnosis)+2 more

Estimated

~$10 – $750

University of California, Los AngelesNCT06191640

Phase 1

Pilot Trial of Stimulant Treatment to Address Attention and Executive Deficits Among Children With Sickle Cell Disease

The purpose of this study is to determine if patients with sickle cell disease (SCD) can consistently take a drug called Methylphenidate (MPH) daily, once a da…

Sickle Cell DiseaseExecutive DysfunctionCognitive Impairment+1 more

Estimated

~$10 – $6,250

St. Jude Children's Research HospitalNCT07226219

Phase 1

A Phase I, Single-dose, Non-randomized, Open-label, Parallel Group Study to Assess the Pharmacokinetics and Safety of Capivasertib in Participants With Moderate Hepatic Impairment

The purpose of this study is to measure the pharmacokinetics (PK), safety, and tolerability of capivasertib in participants with moderate hepatic impairment an…

Moderate Hepatic Impairment

Estimated

~$10 – $7,500

AstraZenecaNCT07343960

Observational

Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity

The purpose of this study is to see if 6 months of home-based walking will improve memory, and brain structure and function, compared to health education in ol…

Mild Cognitive ImpairmentChronic Kidney Diseases

Estimated

~$10 – $6,250

Columbia UniversityNCT05655325