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Natural History of Disorders of Insulin Resistance
The study will allow researchers to obtain blood, plasma, DNA, and RNA for genetic studies of insulin. There will be a focus on the causes of insulin resistanc…
Phase II Trial of the Combination of Alpha-lipoic Acid and Mirabegron in Women and in Men With Obesity
Background: Obesity and related illnesses cause at least 2.8 million deaths each year worldwide. Few treatments exist for obesity that are safe and widely ava…
Effects of Avocado on Triglyceride Metabolism in Individuals With Insulin Resistance
In this study, Investigators are interested in looking at the influence of eating avocados regularly, which are rich in healthy fats, fibers, and unique carboh…
Effect of Endoscopic Sleeve Gastroplasty on Patients With Obesity and Concomitant Metabolic Dysfunction-Associated Steatohepatitis (MASH): A Multicenter, Open-label, Randomized Controlled Trial
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease globally. While weight loss through lifestyle modific…
Reversal of Lipid-Induced Insulin Resistance
The purpose of this study is to examine whether weight reduction decreases intramyocellular (IMCL) and hepatic lipid content, and improves insulin sensitivity …
Interplay of Central and Peripheral Vascular Effects of Insulin in Obesity
In the present study, we seek to determine the impact of obesity with insulin resistance on the neurovascular response to brain insulin stimulation.
Sleep Loss and Circadian Misalignment - Mechanisms of Insulin Resistance
The purpose of this study is to examine the impact of timed cortisol release or differently timed cortisol rhythms on insulin resistance in both men and women …
Exercise Effects on Adipose Tissue Structure and Function
Participants will be randomized into one of two different experimental groups: 1) Exercise group and 2) No exercise (control group). Subject participation in t…
Study of the Effect of Innate Immunity on the Inflammatory Response to Endotoxin
Background: \- Innate immunity is the process by which white blood cells and other parts of the immune system sense and respond to potential infections by cau…
Metabolic Effects of Angiotensin-(1-7)
The overall purpose of this study is to learn more about the metabolic effects of angiotensin-(1-7) in the insulin resistant state associated with obesity. Pha…
Human Models of Selective Insulin Resistance: Graded Insulin Suppression Test (GIST) Pilot & Feasibility Study
The goal of this study is to learn about how the hormone insulin controls blood sugar in a variety of people. The main question it aims to answer is about how …
Pilot Trial of a Risk-informed Shared-decision Engagement Strategy
The goal of this clinical trial is to learn if knowing risk for diabetes can help adult patients with prediabetes take steps to get care and prevent diabetes. …