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6 recruiting studies matching your filters

A Phase Ib Trial of SX-682 (CXCR1/2 Inhibitor) Combined With Proton Craniospinal Irradiation for Patients With Leptomeningeal Disease

The researchers are doing this study to find out whether SX-682 in combination with proton craniospinal irradiation (pCSI) is a safe treatment approach for peo…

Leptomeningeal Disease (LMD)

Estimated

~$10 – $6,250

Memorial Sloan Kettering Cancer CenterNCT07814352

Phase 1

A Phase 1/1b Study of Autologous b7-h3 Chimeric Antigen Receptor t Cells (b7-h3.cd28z.Cart) in Children and Young Adults With Recurrent or Progressive Cns Neoplasms Expressing b7-h3 Target

The purpose of this research study is to test the safety and effectiveness of a cell therapy at different doses for children and young adults with recurrent or…

Central Nervous System NeoplasmsBrain TumorBrain Tumor, Recurrent+11 more

Estimated

~$10 – $7,500

Robbie MajznerNCT07390539

Phase 2

Phase 2 Trial With a Safety Run-in of Combinatorial Therapies With Intrathecal (IT) Dendritic Cell Vaccines (cDC1s) inHER+ (Combined With IT Trastuzumab) and HER2- (Combined With IT Nivolumab) Breast Cancer (BC) Leptomeningeal Disease (LMD)

The purpose of this study is to learn about the effects of the study treatment, Dendritic Cell Vaccine (DCV), in combination with trastuzumab or nivolumab to c…

Breast CancerLeptomeningeal Disease

Estimated

~$10 – $6,250

H. Lee Moffitt Cancer Center and Research InstituteNCT07694986

Phase 2

Traditional Incision and Drainage of Cutaneous Abscess Vs. Minimally Invasive Incision and Drainage With Vessel Loop: A Randomized Controlled Trail

This study is a prospective evaluation of systemic, intravenous high-dose methotrexate (HD-MTX, 8 g/m2) in patients with triple negative, HER2-positive, and ho…

Metastatic Breast CancerLeptomeningeal Disease

Estimated

~$10 – $6,250

Wake Forest University Health SciencesNCT02422641

Observational

Optimizing Contrast Dose and Scanning Parameters for Detection of Leptomeningeal Disease

To learn if gadopiclenol (a contrast agent) used during MRI scanning can help in the detection of early LMD.

Leptomeningeal Disease

Estimated

~$10 – $6,250

M.D. Anderson Cancer CenterNCT07415018

Standardized Clinical Assessment of Patients With Leptomeningeal Metastasis

The goal of this project is to develop and validate a reproducible scorecard for the neurological assessment of patients with leptomeningeal metastases that ca…

Leptomeningeal MetastasisLeptomeningeal DiseaseLeptomeningeal Neoplasms+1 more

Estimated

~$10 – $750

University of ZurichNCT06417710