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31 recruiting studies matching your filters

An Observational Pregnancy Safety Study in Women With Neuromyelitis Optica Spectrum Disorder (NMOSD) Exposed to UPLIZNA® (Inebilizumab-cdon) During Pregnancy

This is an observational study to monitor female participants exposed to UPLIZNA during pregnancy. This study requires voluntary reporting of pregnancies in fe…

Neuromyelitis Optica Spectrum DisorderPregnancy Related

Low-dose Naltrexone (LDN) for the Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Dose-Finding

This exploratory clinical trial tests low-dose naltrexone (LDN) for the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). A remote tria…

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Estimated

~$10 – $6,250

University of Alabama at BirminghamNCT07285473

Phase 4

Prophylactic Antibiotic Coated Nail to Prevent Infection: A Clinical Trial

This prospective randomized clinical trial will compare outcomes between patients treated primarily with a prophylactic antibiotic coated nail and those treate…

Osteomyelitis TibiaTibial FracturesOpen Tibia Fracture

Estimated

~$10 – $6,250

Wake Forest University Health SciencesNCT05421741

Phase 3

A Phase III, Multicenter, Open-Label, Uncontrolled Study To Evaluate Pharmacokinetics, Efficacy, Safety, Tolerability, And Pharmacodynamics Of Satralizumab In Pediatric Patients With AQP4 Antibody Positive Neuromyelitis Optica Spectrum Disorder (NMOSD)

This study will primarily evaluate the pharmacokinetics of satralizumab in pediatric patients aged 2-11 years with anti-aquaporin-4 (AQP4) antibody seropositiv…

Neuromyelitis Optica Spectrum DisorderNMOSD

Estimated

~$10 – $7,500

Hoffmann-La RocheNCT05199688

Phase 4

Comparing Optimal Step-down Therapy for Children With Invasive MRSA Trimethoprim-Sulfamethoxazole vs. Clindamycin for the Treatment of Children With Invasive MRSA Infections

The goal of this clinical trial is to learn if trimethoprim-sulfamethoxazole (TMP-SMX) works to treat invasive infections due to methicillin-resistant Staphylo…

Methicillin Resistant Staphylococcus AureusOsteomyelitis AcuteSeptic Arthritis+6 more

Estimated

~$10 – $6,250

Indiana UniversityNCT06982105

Observational

A Multi-center, Single-arm, Historically Controlled Pivotal Trial, to Assess the Safety and Effectiveness of Genex G as Part of the Surgical Treatment of Osteomyelitis of the Extremities.

The purpose of this trial is to determine if genex with gentamicin (genex G) an antibiotic loaded bone void filler, works to treat and is a safe option as part…

Osteomyelitis

Estimated

~$10 – $8,750

Biocomposites LtdNCT07270380

Phase 1

A Phase 1/2a Open-Label Study to Investigate the Safety of the Transplantation (by Injection) of Human Glial Restricted Progenitor Cells (hGRPs; Q-Cells®) Into Subjects With Transverse Myelitis (TM)

This study is a non-randomized, open-label, partially blinded, sequential cohort, dose-escalation study designed to obtain preliminary data on the safety, tole…

Transverse Myelitis

Estimated

~$10 – $8,750

Q Therapeutics, Inc.NCT03887273

Phase 3

Intramedullary Calcium Sulfate Antibiotic Depot for Prevention of Open Fracture Related Infection: A Randomized Clinical Trial

The goal of this randomized clinical trial is to study the best treatment for open lower leg fractures to prevent infection. The main questions it aims to answ…

Open tíbia FractureOsteomyelitis TibiaTibial Fractures

Estimated

~$10 – $6,250

Wake Forest University Health SciencesNCT05766670

Phase 3

A Randomized Controlled, Open-Label, Rater-Blinded Pragmatic Trial, Treatment of Inflammatory Myelitis and Optic Neuritis With Early vs Rescue Plasma Exchange (TIMELY-PLEX)

The purpose of this research is to evaluate if early vs rescue Therapeutic Plasma Exchange (PLEX) treatment algorithm leads to better visual outcomes in severe…

Optic NeuritisMyelitisMyelitis, Transverse

Estimated

~$10 – $6,250

Mayo ClinicNCT07100990

A Long-Term, Prospective, Observational, Registry of Patients With Anti-Aquaporin 4 Antibody-Positive (AQP4+) Neuromyelitis Optica Spectrum Disorder (NMOSD) Treated With Alexion Complement Component 5 (C5) Inhibitor Therapies (ALXN-C5IT)

Long-term, multicenter, multinational, observational, registry of patients with AQP4+ NMOSD that is designed to collect data on clinical outcomes and safety in…

Neuromyelitis Optica Spectrum DisorderNMOSDAQP4+ NMOSD

Estimated

~$10 – $1,050

Alexion Pharmaceuticals, Inc.NCT05966467

Longitudinal Investigation of Cortical Demyelination and Meningeal Inflammation in Multiple Sclerosis and Related Disorders

In this protocol, a combination of MRI, blood, and cerebrospinal fluid (CSF) analysis will be used to understand the natural history, underlying immunologic me…

Multiple SclerosisNeuromyelitis OpticaDemyelinating Autoimmune Diseases, CNS

Estimated

~$10 – $750

Icahn School of Medicine at Mount SinaiNCT05982925

A Pilot, Post-market, Non-interventional, Prospective, Observational Study of Standard of Care of the Commercially Available Borate-base Bioactive Glass Fiber Matrix (BBGFM) in Treatment of Outpatient Diabetic Foot Ulcer With Chronic Osteomyelitis.

This study is being done to collect data from treatment of patients who have diabetes with non-healing foot wounds and are being treated with a resorbable and …

Diabetic Foot UlcerOsteomyelitis Chronic

Estimated

~$10 – $750

The University of Texas Health Science Center at San AntonioNCT06598241