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Sociocultural & Biobehavioral Influences on Pain Expression and Assessment
Objective The current proposal investigates behavioral, psychophysiological, and social processes that may help explain biases and disparate outcomes in pain.…
Perception, Sensation, Cognition and Action in Humans
Background: When people see and hear, the brain changes signals from the eyes and ears into perceptions and thoughts. No one fully understands how this happen…
Causal Mechanisms of Odor-Guided Behavior in Humans
Background: Little is known about how different regions of the brain responsible for the human sense of smell guide behaviors. In this study, researchers use …
Characterization of an Optically Pumped Magnetometer (OPM) Magnetoencephalography (MEG) Array
Background: Brain activity produces magnetic fields. These fields can be measured outside the head. Existing technology, called MEG, measures these fields. Re…
Developing Transcranial Neuromodulation Protocols for Learning and Decision-Making
Background: People with substance use disorder (SUD) often have changes in brain function that can make it difficult to control drug-seeking behavior. These c…
Development of Neuroimaging Methods to Assess the Neurobiology of Addiction
Background: Abusing alcohol, drugs, and other substances can cause serious health problems. These substances also can affect brain function. Researchers want …
Investigational Use of Neuromuscular Ultrasound
Background: Current techniques used to measure the health and function of a person s nerves and muscles are generally effective, but they do have limits. Rese…
Assessing and Improving Quantitative Magnetic Resonance Imaging Metrics in Human Subjects
Background: Magnetic resonance imaging (MRI), which uses strong magnets to get images of structures inside the body, is a valuable tool in modern medicine. Bu…
An All-Night Functional Magnetic Resonance Imaging Sleep Study With Auditory Stimuli
Background: An electroencephalogram (EEG) measures the brain s electrical activity. EEG shows that the louder the sound needed to wake a person, the deeper th…
Clinical and Scientific Assessment of Pain and Painful Disorders
Background: Researchers want to better understand pain by studying people with and without different kinds of pain. To do this, researchers will expose people…
Defining Neurobiological Links Between Substance Use and Mental Illness
Background: Nicotine dependence leads to about 480,000 deaths every year in the United States. People with major depressive disorder (MDD) are twice as likely…
Neural and Psychological Mechanisms of Pain Perception
Background: \- Painful stimuli cause changes in a network of brain regions called the "Pain Matrix." But most of these regions respond to many other stimuli, …