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Defining Neurobiological Links Between Substance Use and Mental Illness
Background: Nicotine dependence leads to about 480,000 deaths every year in the United States. People with major depressive disorder (MDD) are twice as likely…
Development of Magnetic Resonance Imaging and Spectroscopy Research Methods for NIA Studies
Background: \- Magnetic resonance imaging (MRI) studies provide important information on the structure and function of various body systems, including the bra…
An All-Night Functional Magnetic Resonance Imaging Sleep Study With Auditory Stimuli
Background: An electroencephalogram (EEG) measures the brain s electrical activity. EEG shows that the louder the sound needed to wake a person, the deeper th…
Causal Mechanisms of Odor-Guided Behavior in Humans
Background: Little is known about how different regions of the brain responsible for the human sense of smell guide behaviors. In this study, researchers use …
Clinical and Scientific Assessment of Pain and Painful Disorders
Background: Researchers want to better understand pain by studying people with and without different kinds of pain. To do this, researchers will expose people…
Characterization of an Optically Pumped Magnetometer (OPM) Magnetoencephalography (MEG) Array
Background: Brain activity produces magnetic fields. These fields can be measured outside the head. Existing technology, called MEG, measures these fields. Re…
Influence of Brain Oscillation-Dependent TMS on Motor Function
Background: When people have a stroke, they often have difficulty moving their arms and hands. Transcranial magnetic stimulation (TMS) can improve how well pe…
Investigating the Impact of Obesity on Pubertal Development in Girls
Background: Studies suggest that overweight girls may be developing breast tissue, and therefore starting puberty, earlier than normal weight girls. However, …
Perception, Sensation, Cognition and Action in Humans
Background: When people see and hear, the brain changes signals from the eyes and ears into perceptions and thoughts. No one fully understands how this happen…
Neural and Psychological Mechanisms of Pain Perception
Background: \- Painful stimuli cause changes in a network of brain regions called the "Pain Matrix." But most of these regions respond to many other stimuli, …
Investigational Use of Neuromuscular Ultrasound
Background: Current techniques used to measure the health and function of a person s nerves and muscles are generally effective, but they do have limits. Rese…
A Natural History Study of Metabolic Sizing in Health and Disease
Background: Scientists have long used simple measures (such as height and weight) to estimate how much a person s body uses food (calories) as energy, as comm…