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322 recruiting studies matching your filters

A Phase 1/2, First-in-Human Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of OCT-980 in Healthy Volunteers and Participants With Autosomal Dominant Retinitis Pigmentosa

This integrated Ph1/2 clinical study is to assess the safety, tolerability and pharmacokinetics (PK), pharmacodynamics (PD) and efficacy of OCT-980 in healthy …

Retinitis Pigmentosa

Estimated

~$10 – $8,750

Octant, Inc.NCT07408232

Phase 1

A Phase I/IIa, Dose Escalation Study Evaluating the Safety, Tolerability, and Preliminary Efficacy of Intraductal Administration of RXRG001 to Parotid Gland(s) in Adults With Radiation-Induced Xerostomia and Hyposalivation

This is a first-in-human clinical study to evaluate the safety, tolerability and efficacy of RXRG001 administered in the ducts of the parotid glands in adult p…

Radiation-Induced Xerostomia and Hyposalivation

Estimated

~$10 – $8,750

RiboX Therapeutics Ltd.NCT06714253

Early Dental Risk Screening for Pediatric Sleep-Disordered Breathing

This is a prospective, cross-sectional observational study designed to evaluate the Pediatric Sleep Questionnaire (PSQ) as a screening tool for sleep-disordere…

Early Risk Screening for Sleep Disordered Breathing in a Dental SettingSleep Disordered Breathing (SDB)Obstructive Sleep Apnea (OSA)

Estimated

~$10 – $750

University of North Carolina, Chapel HillNCT07581938

An Exploratory Study of the Genetics, Pathophysiology, and Natural History of Autoinflammatory Diseases

This study is designed to explore the genetics and pathophysiology of diseases presenting with intermittent fever, including familial Mediterranean fever, TRAP…

Familial Mediterranean Fever (FMF)AutoinflammationPeriodic Fever+4 more

Estimated

~$10 – $675

National Human Genome Research Institute (NHGRI)NCT00001373

Phase 2

Phase II, Randomized, Double-Blind, Multidose Crossover Clinical Trial to Determine the Safety and Efficacy of IHL-42X in Subjects With Obstructive Sleep Apnea

The goal of this randomized, double-blind, multi-dose crossover clinical trial is to determine the safety and efficacy of IHL-42X in subjects with obstructive …

Obstructive Sleep Apnea (OSA)

Estimated

~$10 – $8,750

Incannex Healthcare LtdNCT07635563

Generation of Induced Pluripotent Stem (iPS) Cell Lines From Somatic Cells of Participants With Eye Diseases and From Somatic Cells of Matched Controls

Background: \- Best Vitelliform Dystrophy (Best disease), Late-Onset Retinal Degeneration (L-ORD), and Age-Related Macular Degeneration (AMD) all affect the r…

Retinal DiseaseAMDRetinal Degeneration+1 more

Estimated

~$10 – $675

National Eye Institute (NEI)NCT01432847

Phase 2

A Phase II Trial of the MEK Inhibitor Mirdametinib in Histiocytic Disorders

The purpose of this study is to see if treatment with mirdametinib in patients with Langerhans cell histiocytosis (LCH) or other histiocytic disorders will be …

Langerhans Cell Histiocytosis (LCH)Juvenile Xanthogranuloma (JXG)Rosai-Dorfman Disease (RDD)+1 more

Estimated

~$10 – $5,625

Children's Hospital Medical Center, CincinnatiNCT06153173

Phase 2

Phase II Study of Enasidenib in IDH2-mutated Malignant Sinonasal and Skull Base Tumors

Background: Cancers of the nasal cavity or skull base are rare. They often are not diagnosed until they are at an advanced stage, and they often spread to oth…

Metastatic ChondrosarcomaLocally Advanced ChondrosarcomaMetastatic Sinonasal Adenocarcinoma+7 more

Estimated

~$10 – $5,625

National Cancer Institute (NCI)NCT06176989

Phase 1

A Phase 1/1b Study Evaluating the Safety, Tolerability, and Pharmacokinetics of AMG 436 as Monotherapy and in Combination With Other Therapies in Participants With Microsatellite Instability-high (MSI-H)/Mismatch Repair Deficient (dMMR) Solid Tumors

The primary objectives of this trial are to evaluate the safety profile of AMG 436 and to determine the maximum tolerated dose (MTD) and/or the recommended dos…

Metastatic or Locally Advanced Solid Tumors With Microsatellite Instability-high (MSI-H) or Mismatched Repair Deficiency (dMMR)

A Randomized, Dose-Ranging Trial of Propofol-Only and Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging

The most common imaging procedure requiring sedation/anesthesia for the pediatric population is magnetic resonance imaging (MRI). However, the optimal anesthet…

MRI SedationPediatric SedationPropofol Dosage+3 more

Estimated

~$10 – $6,250

Boston Children's HospitalNCT07369128

Phase 1

A Phase Ib Open Label Clinical Trial to Evaluate the Safety and Efficacy of ERAS-801 in Recurrent Glioblastoma or Elderly Newly Diagnosed Glioblastoma Patients With EGFR Amplification and/or Mutation (ERAS-801-3.0)

This phase Ib trial tests the safety and side effects of ERAS-801 in treating patients with isocitrate dehydrogenase (IDH) wildtype, epidermal growth factor re…

GlioblastomaGlioblastoma, IDH-WildtypeGliosarcoma+3 more

Estimated

~$10 – $6,250

Jonsson Comprehensive Cancer CenterNCT07089641

Observational

Evaluation of the F&P Licorice Mask, US, 2026

This clinical investigation is designed to validate and confirm the overall performance, safety, usability, reliability, and acceptability of the F\&P Licorice…

Chronic Respiratory ConditionsObstructive Sleep Apnea (OSA)

Estimated

~$10 – $7,500

Fisher and Paykel HealthcareNCT07826429