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Study of the Phenotype of Overweight and Obese Adults
This study will describe the phenotype (physical and behavioral traits) of overweight and obese people. It will characterize the hormones, metabolism, food pre…
A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Oral KAI-7535 in Adult Participants Living With Obesity or Overweight With at Least 1 Weight-Related Comorbidity
The primary objective of this study is to determine the efficacy of oral KAI-7535 once daily compared with placebo on percent change in body weight in particip…
Effect of Time-based Energy Intake Goals on Weight Loss During Obesity Treatment
The goal of this randomized controlled trial is to learn how the time of day when calories are eaten affects weight loss in the long-term (12 months). The main…
Exercise Effects on the Neurobiology Underlying Stress-Related Eating Behaviors in Veterans
The purpose of this study is to learn more about how common lifestyle interventions, such as exercise, affect how our brains respond to performing thinking tas…
Variability In Mixed Meal Tests: Fixed Versus Adjusted to Energy Needs Caloric Dose
Background: Researchers use mixed meal tolerance tests (MMTTs) to look at how people s bodies respond to eating a meal. However, researchers do not agree on h…
A Phase 3 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Maridebart Cafraglutide in Adult Participants With Obstructive Sleep Apnea on Positive Airway Pressure Therapy and Living With Overweight or Obesity
This Phase 3 clinical trial is designed to evaluate the efficacy and safety of maridebart cafraglutide compared to placebo over a 52-week period in adults with…
MODERN-Dental: Pediatric Obesity, Cardiometabolic Risks, And Periodontal Disease: Effects Of Semaglutide Treatment
The goal of this clinical trial is to assess whether adjunctive dental cleaning can enhance the effects of semaglutide in children with obesity. The main quest…
The Michigan Weight Navigation Program (MiWeigh) Study
The main purpose of this study is to determine whether people who participate in MiWeigh lose more weight than people who receive information about weight loss…
Dietary Insights and Nutritional Education in Adults on GLP-1 Therapy
This pilot study will evaluate the feasibility, acceptability, and perceived usefulness of the SWITCH mobile nutrition behavioral intervention among adults rec…
Tirzepatide's Role in Postmenopausal HR+ Breast Cancer Survivors
This study will explore whether tirzepatide is a practical and acceptable treatment for postmenopausal females with a history of hormone receptor-positive brea…
Physiology of the Weight Reduced State
The goal of this clinical trial is to determine the physiological basis for the differences in weight regain among adults (25-59 years old) with obesity follow…
Advancing Water Security: A Community Participatory School-Based Hydration Intervention
The goal of this study is to determine the effectiveness and sustainability of a community-participatory hydration intervention over 3 years within a district …