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235 recruiting studies matching your filters

Adaptive Decision Support for Addiction Treatment (ADAPT)

This study refines and optimizes the EMBED\* clinical decision support (CDS; see NCT03658642) to increase number of ED physicians following standard of care fo…

Opioid Use Disorder

Estimated

~$10 – $6,250

Yale UniversityNCT06799117

Observational

Longitudinal Neural Fingerprinting of Opioid-use Trajectories

This project aims to collect a densely sampled neuroimaging dataset among individuals receiving medications for opioid use disorder (MOUD). MOUD is multiphasic…

Opioid Use Disorder

Estimated

~$10 – $6,250

Yale UniversityNCT06207162

Phase 3

A Comparative Effectiveness Trial of Sublingual Versus Extended-release Buprenorphine With Individuals Leaving a Carceral Setting

This study is an open label randomized controlled trial of extended-release buprenorphine (BRIXADI, XR-B) vs. sublingual buprenorphine (SL-B) in a large metrop…

Opioid Use Disorder

Estimated

~$10 – $8,750

Friends Research Institute, Inc.NCT06306443

Phase 1

A Phase 1, First-In-Human, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Ascending Doses of MCAM in Randomized Healthy Adult Participants (Double-Blind)

The goal of this clinical trial is to test the safety and to see if there are any side effects of the investigational drug, MCAM. The main aim is to measure bl…

Opioid Use Disorder

Estimated

~$10 – $6,250

The University of Texas Health Science Center at San AntonioNCT07602335

Phase 3

Dronabinol and Epidiolex to Manage Uncontrolled Residual Symptoms of Buprenorphine Initiation Trial

The goal of this pilot study is to test novel, adjunctive pharmacotherapy for patients with opioid use disorder (POUD) who may be at risk for overdose and othe…

Opioid Use Disorder

Estimated

~$10 – $6,250

Montefiore Medical CenterNCT07148206

Observational

Postpartum Intervention for Mothers With Opioid Use Disorders (R33)

Having met the milestones of the R61, this R33 is a 2-site, 2-group, pre/post RCT of mothers with OUD (n=\~80/group). We will test whether the beneficial pre-p…

Opioid Use DisorderParent-Child Relations

Estimated

~$10 – $6,250

Stony Brook UniversityNCT07632053

Observational

Adaptive Decision Support for Addiction Treatment (ADAPT) Serial Randomized Testing for Usability, Round 2

This study is stage 2, round 2 of a larger study which refines and optimizes the EMBED clinical decision support (CDS); see NCT03658642 to increase number of E…

Opioid Use DisorderClinical Decision Support

Estimated

~$10 – $6,250

Yale UniversityNCT07602218

Observational

Better Experiences in Substance Treatment: A Brief Alcohol-Focused Intervention Tailored for Patients in Opioid Agonist Treatment

This study will help determine the feasibility and acceptability of a brief opioid-informed alcohol intervention in patients receiving prescribed buprenorphine…

Alcohol Use DisorderOpioid Use DisorderAlcohol Use+1 more

Estimated

~$10 – $6,250

University of Notre DameNCT07342504

Phase 3

ED-Initiated Standard Versus High Dose Buprenorphine Induction

This study is a multisite double-blind, double-dummy, randomized clinical trial enrolling ED patients with untreated moderate to severe opioid use disorder (OU…

Opioid Use Disorder

Estimated

~$10 – $6,250

Yale UniversityNCT06494904

Phase 1

A Randomized Controlled Trial Examining Extended-Release Injectable Buprenorphine in Those Who Use High Potency Synthetic Opioids

The goal of this clinical trial is to compare buprenorphine formulations (sublingual buprenorphine versus long-acting injectable buprenorphine) for treating op…

Opioid Use Disorder

Estimated

~$10 – $7,500

Rachel R. LubaNCT06726200

Phase 4

A Randomized Control Trial for Opioid Use After Laparoscopic Salpingectomy

The purpose of this study is to evaluate patient-reported post-operative pain scores following minimally invasive tubal sterilization procedures to determine i…

Opioid UsePost-operative PainSterility, Female

Estimated

~$10 – $6,250

Johns Hopkins UniversityNCT06434233

Impact of Patient Phenotypic Features on the Experience and Effectiveness of Regional Anesthesia and Postoperative Pain

The goal of this observational study is to learn about how regional anesthesia (numbing medication) affects pain in patients with different psychosocial phenot…

Acute PainChronic Post Operative PainOpioid Use

Estimated

~$10 – $750

Brigham and Women's HospitalNCT06466941