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185 recruiting studies matching your filters

Ketone Supplementation for Opioid Craving and Withdrawal

The goal of this clinical trial is to learn if ketone supplementation (KS) works to reduce craving for opioids for adults with opioid use disorder (OUD) underg…

Opioid Use Disorder

Estimated

~$10 – $6,250

University of Maryland, BaltimoreNCT07128524

Observational

CTN-0156: Pilot Development and Evaluation of a Patient Decision Aid for Emergency Department Initiated Buprenorphine

This study aims to develop and pilot test a patient decision aid (PtDA) for emergency department (ED)-initiated buprenorphine treatment for opioid use disorder…

Opioid Use Disorder

Estimated

~$10 – $6,250

Medical University of South CarolinaNCT07278518

Phase 2

Evaluating a Mechanistically-Supported Pharmacotherapy to Treat Opioid Withdrawal

The investigators propose a rigorous, Phase II, three-group, placebo-controlled double-blind randomized controlled trial (RCT) to evaluate the efficacy of busp…

Opioid Use DisorderOpioid WithdrawalOpioid Craving+1 more

Estimated

~$10 – $6,250

University of Maryland, BaltimoreNCT05511909

Observational

A Pilot Randomized Controlled Trial to Improve Outpatient Initiation of Medication for Opioid Use Disorder (MOUD) Following Hospitalization: The TRTME (Tailored Overdose Risk Feedback, Testimonials for MOUD Treatment, and Education on MOUD and Opioid Overdose) Trial

The primary objective of this study is to evaluate the ability of TRTME to increase initiation of MOUD outpatient treatment and MOUD knowledge in hospitalized …

Opioid Use DisorderOpioid Use Disorder, ModerateOpioid Use Disorder, Severe

Estimated

~$10 – $7,500

T. John Winhusen, PhDNCT07780097

Phase 1

Cannabis and Opioid Use Disorder, Study 2

This inpatient study enrolls healthy individuals who have opioid use disorder. Participants live at the University of Kentucky Hospital for approx. 6 weeks. Du…

Opioid Use DisordersCannabis Use

Estimated

~$10 – $6,250

University of KentuckyNCT07661446

Phase 1

Impact of Cannabis on Opioid Self-Administration

The study will enroll participants with opioid use disorder and participants will reside at the University of Kentucky Hospital for this 6-week inpatient trial…

Opioid Use DisorderCannabis Use

Estimated

~$10 – $7,500

Shanna Babalonis, PhDNCT07668635

Observational

Early Detection of Neonatal Opioid Withdrawal Syndrome Using a Novel Cerebral Monitor.

This study will use a new device to measure blood flow and oxygen levels in the brains of newborn infants who have had exposure to opioid medications in the wo…

Neonatal Opioid WithdrawalNeonatal Opioid Withdrawal SyndromeOpioid Use Disorder+1 more

Estimated

~$10 – $6,250

Indiana UniversityNCT07610746

Observational

Real-world Assessment of Social Functioning During OUD Treatment: Integrating Reports From Patients and Their Concerned Significant Others

Problems with social functioning are core to opioid use disorder (OUD), though specific, modifiable social functioning targets and how they relate to OUD treat…

Opioid Use Disorder

Estimated

~$10 – $6,250

Medical University of South CarolinaNCT07044466

Development of an Opioid Withdrawal Clinical Outcome Assessment Among Persons With Opioid Use Disorder

Withdrawal management strategies are currently the most utilized and ubiquitous intervention for opioid use disorder in the US, yet existing measures of opioid…

Opioid Use Disorder

Estimated

~$10 – $750

University of Maryland, BaltimoreNCT07094672

Phase 2

NIDA CTN-0152: Evaluation of Tirzepatide as an Adjunct to Buprenorphine for the Treatment of Opioid Use Disorder: A Pragmatic, Multi-site, Double-blind, Randomized, Placebo-controlled Trial (TAB)

The primary objective of this research study is to evaluate the effect of tirzepatide, relative to placebo, as an adjunct to BUP on retention, substance use, a…

Opioid Use DisorderOpioid Use Disorder, ModerateOpioid Use Disorder, Severe

Estimated

~$10 – $7,500

T. John Winhusen, PhDNCT06651177

Medications for Opioid Use Disorder Differentially Modulate Intrinsically Photosensitive Retinal Ganglion Cell Function, Sleep, and Circadian Rhythms: Implications for Treatment (MOUD)

Opioid use disorder (OUD) is a treatable medical illness with three medications FDA approved for treatment. However, persons with OUD report significant sleep …

Opioid Use DisorderSleep Disturbance

Estimated

~$10 – $750

University of Alabama at BirminghamNCT06104280

Phase 4

Assessing Optimal Extended-Release Buprenorphine (XRB) Initiation Points in Jail

This application describes a 3-year, randomized controlled trial. Eligible, consenting adults (N=200) with existing sublingual buprenorphine (SLB) prescription…

Opioid Use Disorder

Estimated

~$10 – $7,500

NYU Langone HealthNCT06051890