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18 recruiting studies matching your filters

A Phase III, Multicentre, Randomised, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Elafibranor in Adult Participants With Primary Sclerosing Cholangitis

The purpose of this study is to find out how well and safely elafibranor works compared to placebo in adult participants with Primary sclerosing cholangitis (P…

Primary Sclerosing Cholangitis

Nemolizumab for the Treatment of Moderate to Severe Chronic Hepatic Pruritus: An Open-Label, Single-Arm, Exploratory Study

The purpose of this research is to investigate the efficacy of nemolizumab in the treatment of adults with moderate to severe chronic hepatic pruritus.

Chronic Hepatic PruritusCholestatic Liver DiseasePrimary Biliary Cholangitis+2 more

Estimated

~$10 – $6,250

Mayo ClinicNCT07843420

Unraveling the Mechanisms Underlying Primary Sclerosing Cholangitis Through a Multidisciplinary, Integrative Research Approach

Background: Primary sclerosing cholangitis is a rare chronic liver disease. It affects the bile ducts of the liver. It can result in bile duct infections, ci…

Primary Sclerosing Cholangitis

Estimated

~$10 – $675

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NCT04685200

Cross-sectional Study for Assessment of MRI Based Biomarkers of Bile Duct Injury and Hepatic Fibrosis in Pediatric Onset Autoimmune Liver Disease

Autoimmune liver diseases (AILD), which include Primary Sclerosing Cholangitis (PSC) and Autoimmune Hepatitis (AIH) are a common etiological factors for chroni…

Autoimmune Liver DiseasePrimary Sclerosing CholangitisAutoimmune Hepatitis

Estimated

~$10 – $675

Children's Hospital Medical Center, CincinnatiNCT03175471

Autoimmune Liver Disease Network for Kids (A-LiNK): Using Patient Data to Transform Care and Improve Outcomes for Children, Adolescents, and Young Adults With Autoimmune Liver Disease

The Autoimmune Liver disease Network for Kids (A-LiNK) is a multi-institutional group with the mission to deliver the best care to kids with pediatric autoimmu…

Autoimmune HepatitisPrimary Sclerosing Cholangitis

Estimated

~$10 – $675

Children's Hospital Medical Center, CincinnatiNCT05750498

Longitudinal Study for the Assessment of MRI Based Biomarkers as a Predictors of Clinical Endpoints in Pediatric Onset Autoimmune Liver Disease

Autoimmune liver diseases (AILD), which include Primary Sclerosing Cholangitis (PSC) and Autoimmune Hepatitis (AIH) are a common etiological factor for chronic…

Autoimmune Liver DiseaseAutoimmune HepatitisPrimary Sclerosing Cholangitis

Estimated

~$10 – $675

Children's Hospital Medical Center, CincinnatiNCT03178630

Phase 2

Detoxification of the Liver in Primary Sclerosing Cholangitis

This study is a clinical trial being done to investigate the efficacy of drug BRS201 (hydroxocobalamin) as a treatment in patients with primary sclerosing chol…

Primary Sclerosing Cholangitis

Estimated

~$10 – $6,250

Brigham and Women's HospitalNCT05835505

Phase 2

Peroxisome Proliferator-Activated Receptor Agonists to Prevent Primary Sclerosing Cholangitis Recurrence After Liver Transplantation

This study aims to determine the efficacy of 36 months once-daily fenofibrate in preventing clinically-detectable recurrence of primary sclerosing cholangitis …

Primary Sclerosing CholangitisLiver Transplant, ComplicationsPSC+1 more

Estimated

~$10 – $6,250

Mayo ClinicNCT06905054

Prospective Observational Study of Primary Sclerosing Cholangitis (PSC) in Children

Primary sclerosing cholangitis (PSC) is a rare liver disease that damages the liver's bile ducts. Bile ducts are tiny tubes that carry bile from the liver to t…

Primary Sclerosing CholangitisLiver DiseasesCholangitis, Sclerosing

Estimated

~$10 – $1,125

Arbor Research Collaborative for HealthNCT04181138

Phase 1

Evaluation of an Oral Microbiota-based Therapeutic as a Treatment Option for Primary Sclerosing Cholangitis

This pilot clinical trial will evaluate the initial safety and feasibility of microbiota transplant therapy (MTT) inpatients with primary sclerosing cholangiti…

Primary Sclerosing Cholangitis

Estimated

~$10 – $6,250

University of MinnesotaNCT06197308

Characterization of Biliary Cell-derived Organoids From Bile of PSC and Non-PSC Patients

The purpose of this research is to create a collection of bile, bile duct brushings and medical information from people with Primary Sclerosing Cholangitis (PS…

Primary Sclerosing CholangitisPSCCholangiocarcinoma

Estimated

~$10 – $750

Mayo ClinicNCT04753996

Phase 1

The Human Gastrointestinal Tract Microbiota in the Setting of Treating Primary Sclerosing Cholangitis and Biliary Atresia With Vancomycin

The purpose of this study is twofold. First, is to determine whether vancomycin is effective in the early treatment of Biliary Atresia (BA) and Primary Scleros…

Primary Sclerosing CholangitisBiliary Atresia

Estimated

~$10 – $7,500

Sacramento Pediatric GastroenterologyNCT02137668