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396 recruiting studies matching your filters

INFINITIVE: ImmuNotherapy For PatIeNts wIth colorecTal LIVer MEtastases

Nelitolimod is a classC toll-like receptor 9 (TLR9) agonist that binds to TLR9 receptors on myeloid-derived suppressor cells(MDSCs) and helps reshape the tumor…

Colorectal Cancer Metastatic

Estimated

~$10 – $7,500

Northwell HealthNCT07172282

Phase 2

Sequential Combined TAS-102 and Oxaliplatin Alternating With TAS-102 and Irinotecan (Sequential TASOXIRI) With Bevacizumab for Late-Line Metastatic Colorectal Cancer

This study is to evaluate the disease control rate and time to progression of the sequential combination of oxaliplatin with an alternative anti-metabolite Tri…

Colon CancerRectal Cancer

Estimated

~$10 – $6,250

Rutgers, The State University of New JerseyNCT05806931

Observational

Symptom Management and Transitioning to Engagement With Post-treatment Care for Adolescent and Young Adult Cancer Survivors

The purpose of this study is to determine the effectiveness of a digital health program called AYA STEPS, which is designed to help adolescent and young adult …

CancerBreast CancerColorectal Cancer+3 more

Estimated

~$10 – $6,250

Duke UniversityNCT06371768

ColoSense Post Approval Study

The post-approval study (PAS) described here will supplement existing data generated in the CRC-PREVENT clinical trial. The primary outcomes of this supplement…

Colorectal Cancer (Diagnosis)

Estimated

~$10 – $1,050

Geneoscopy, Inc.NCT07069556

Phase 1

A Phase I/Ib Trial of ProAgio, an Anti-avb3 Integrin Cytotoxin, in Combination With 5-fluorouracil , Irinotecan and Bevacizumab for Advanced/Metastatic Colorectal Cancer (ProAgio in CRC)

This is an open-label Phase I/Ib dose-escalation, dose-expansion clinical trial of the safety, pharmacokinetics and clinical activity of ProAgio combined with …

Advanced Colorectal CancerMetastatic Colorectal Cancer

Estimated

~$10 – $6,250

University of Alabama at BirminghamNCT06867822

Translational Utility of Tumor-Derived FGF19 in a Novel Blood-Based Endocrine Suppression Approach

Identify and test thresholds, specificity and sensitivity for a potential cancer associated biomarker protein, FGF19, (and associated markers) for detection in…

Colorectal CancerBreast CancerHealthy

Estimated

~$10 – $750

University of Central FloridaNCT06068257

Phase 2

Phase IIa Study of Safety/Feasibility of a Hybrid Model of Tertiary and Community Delivery of Hepatic Artery Infusion Chemotherapy

The goal of this clinical trial is to help learn about the safety and feasibility of hepatic artery infusion chemotherapy for those who have colorectal liver m…

Colorectal Cancer MetastaticIntrahepatic Cholangiocarcinoma

Estimated

~$10 – $7,500

Michael J Cavnar, MDNCT07201519

Early-Onset Colorectal Cancer Patients Too Young for Screening: Outcomes and Treatment Patterns

This is a population-based retrospective study using the Surveillance, Epidemiology, and End Results (SEER) registry and National Cancer Data Base (NCDB) to lo…

Colorectal Cancer

Estimated

~$10 – $750

Methodist Health SystemNCT07559825

Observational

An International Multicenter Randomized Controlled Trial to Compare Combined Portal and Hepatic Vein Embolization (PVE/HVE) with PVE Alone in Patients with Colorectal Liver Cancer Metastases (CRLM) and a Small Future Liver Remnant (FLR)

In the randomized controlled DRAGON 2 trial study subjects will be randomized between two arms, PVE alone (control group) and PVE/HVE (interventional group).

Colorectal Cancer Liver Metastases (CRLM)Small Future Liver Remnant (FLR)

Estimated

~$10 – $6,250

Maastricht UniversityNCT05428735

Phase 1

A Phase I Study of Trifluridine/ Tipiracil Plus the Poly (ADP) Ribose Polymerase Inhibitor Talazoparib in Advanced Cancers

This phase I trial investigates the side effects and best dose of talazoparib when given together with trifluridine/tipiracil for the treatment of patients wit…

Advanced Malignant Solid NeoplasmClinical Stage III Gastroesophageal Junction AdenocarcinomaClinical Stage IV Gastroesophageal Junction Adenocarcinoma+26 more

Phase 1

Phase I/II Study of Epacadostat (INCB024360) Added to Preoperative Chemoradiation in Patients With Locally Advanced Rectal Cancer

The purpose of this research study is to evaluate epacadostat when given with routine radiation therapy and chemotherapy (capecitabine and oxaliplatin) to trea…

Rectal Cancer

Estimated

~$10 – $6,250

Washington University School of MedicineNCT03516708

Observational

Randomized Controlled Trial of Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes

Patients with digestive tract malignancy often experience severe and unremitting abdominal pain that negatively affects physical, emotional, and social functio…

Cancer PainVisceral PainGastrointestinal Neoplasms+76 more