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Somatic Mosaicism in Twins Discordant for Childhood Cancer: a Pilot Study
Somatic mosaicism in cancer associated genes is one potential explanation for discordance in childhood cancer that has not been fully explored to date. This pi…
Pediatric Central Nervous System TumorCentral Nervous System TumorDiscordant Twin+1 more
Children's Oncology GroupNCT06054295
Observational
Healthy Futures Research Study: Linking Somatic Mutation Rate With Baseline Exposure in East Palestine
The goal of this study is to This research team is conducting this study to develop methods to measure the biological impact of exposure to the chemicals relea…
Somatic Mutation
Case Comprehensive Cancer CenterNCT06357845
UCSF Biobank for Studying Hereditary Cancers and Tumor-Associated Mutations
This is a non-therapeutic clinical research biorepository protocol designed to obtain, store, and clinically annotate biospecimens from participants with hered…
Solid TumorSolid Tumor, AdultSomatic Mutation+2 more
University of California, San FranciscoNCT06895681
Phase 2
Phase II, Open-Label, Prospective Study of T Cell Receptor Alpha/Beta Depletion (A/B TCD) Peripheral Blood Stem Cell (PBSC) Transplantation for Children and Adults With Hematological Malignancies
This is a phase II, open-label, prospective study of T cell receptor alpha/beta depletion (TCR α/β TCD) peripheral blood stem cell (PBSC) transplantation for c…
Hematologic MalignancyAcute LeukemiaRemission+21 more
Masonic Cancer Center, University of MinnesotaNCT05735717