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Phase 1
Type 2 Diabetes Mellitus and Blood Brain Barrier Improvement - A Randomized Clinical Trial
The majority of T2DM adults show thiamine (vitamin B1) deficiency which may contribute to impaired function. This study will examine patients with T2DM through…
Type2diabetes
University of California, Los AngelesNCT06322212
Phase 2
The Effect of rs7903146 Genotype on Islet GLP-1 Production in Humans
The investigators recently demonstrated that blockade of Glucagon-Like Peptide-1's (GLP-1) receptor (GLP1R) results in changes in islet function without change…
Genetic PredispositionType2diabetes
Mayo ClinicNCT06972407
Phase 2
The Effects of Glucagon on Hepatic Metabolism in People With Type 2 Diabetes After Caloric Restriction
Caloric restriction (and RYGB) improves insulin action and lowers fasting glucose, glucagon and EGP, without changes in postprandial EGP and glucagon concentra…
Type2diabetes
Adrian VellaNCT05499702