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AN OPEN-LABEL PHASE 1 STUDY TO EVALUATE PF-07994525 IN PARTICIPANTS WITH ADVANCED MALIGNANCIES

This is an open-label, dose escalation and dose expansion study evaluating the safety, tolerability, Pharmacokinetic (PK), Pharmacodynamic (PD), and antitumor …

Advanced MalignanciesAdvanced Cancer

Limited Versus Extended Trophic Feeding (LET-FEED) Trial

Study Hypothesis/Question In infants born very preterm, advancing enteral feeds after 24 hours from birth (limited trophic feeds) versus after 72 hours (extend…

SepsisLength of StayMortality+1 more

Estimated

~$10 – $6,250

University of WashingtonNCT06893939

Phase 1

AN INTERVENTIONAL PHASE 1B/2, OPEN-LABEL STUDY TO INVESTIGATE THE SAFETY, ANTITUMOR ACTIVITY, AND PHARMACOKINETICS OF PF 08634404 MONOTHERAPY OR IN COMBINATION WITH ENFORTUMAB VEDOTIN IN ADULT PARTICIPANTS WITH LOCALLY ADVANCED OR METASTATIC UROTHELIAL CANCER

This study is being done to learn more about a new medicine called PF-08634404. It is for adults with a type of bladder cancer called locally advanced or metas…

Urothelial CancerAdvanced/Metastatic Urothelial CancerUrothelial Carcinoma

A Phase 1, 2-Part, Multicenter, Open-Label, First-in-Human Study of the Anti-Ly6E Exatecan Antibody-Drug Conjugate M7437 in Participants With Advanced Solid Tumors

The purpose of this first-in-human (FIH) study is to evaluate the safety, tolerability, Pharmacokinetics (PK), and preliminary clinical activity of M7437 in pa…

Advanced Solid Tumors

Estimated

~$10 – $8,750

EMD Serono Research & Development Institute, Inc.NCT07360314

Establishment of Age-, Sex-, and Education-Stratified Normative Data for a Fully Digital Voice-Recognized Neurocognitive Testing Platform in Adults Aged 18-100 Years

Trial weblink: https://www.memoryexam.com/job/norms/ Participants enrolled in this study will complete a single-session, non-invasive, computerized cognitive …

CognitionCognition DisordersCognition - Other+4 more

Estimated

~$10 – $1,125

The Neurology Center of Southern CaliforniaNCT07763392

Phase 3

A Phase 3 Randomized, Double-Blind, Active-Controlled Study of Palazestrant With Ribociclib Versus Letrozole With Ribociclib for the First-Line Treatment of ER+, HER2- Advanced Breast Cancer (OPERA-02)

This phase 3 clinical trial compares the efficacy and safety of palazestrant with ribociclib to letrozole and ribociclib in women and men who have not received…

Breast CancerLocally Advanced Breast CancerMetastatic Breast Cancer+2 more

Estimated

~$10 – $8,750

Olema Pharmaceuticals, Inc.NCT07085767

Host Response to Infection and Treatment in the Filarial Diseases of Humans

This study will evaluate and treat patients with filarial infections to explore in depth the immunology of the disease, including susceptibility to infection, …

FilariasisHelminthiasisParasitic Infection+2 more

Estimated

~$10 – $675

National Institute of Allergy and Infectious Diseases (NIAID)NCT00001230

Observational

A Randomized Controlled Trial of Music-4-MS Compared to Music Listening to Improve Cognition in People Living With Multiple Sclerosis: A Feasibility Study

Multiple sclerosis (MS) rates in the U.S. have nearly doubled over the past decade, making it a leading cause of nontraumatic functional impairment in young ad…

Multiple SclerosisPathologic ProcessesDemyelinating Autoimmune Diseases, CNS+5 more

Estimated

~$10 – $6,250

University of Texas at AustinNCT07759115

Observational

Treatment of Acquired Idiopathic Stiffness in Revision Total Knee Arthroplasty With Hinged Knee Prosthesis With or Without Low Dose Irradiation: A Multicentre Prospective Randomized Controlled Trial

Acquired idiopathic stiffness (AIS) is a common complication following total knee arthroplasty (TKA). It is caused by excessive scar formation, which leads to …

Arthrofibrosis of Knee

Estimated

~$10 – $6,250

Mount Sinai Hospital, CanadaNCT07767097

Phase 1

Phase 1b/2, Multicenter, Double-Blind, Placebo-Controlled, Multiple Dose Study Assessing the Pharmacokinetics, Safety, Pharmacodynamics, and Efficacy of HS235 in Obese Participants With Pulmonary Hypertension and HFpEF

Study of HS235 in Obese Participants with Pulmonary Hypertension and Heart Failure with Preserved Ejection Fraction

Pulmonary HypertensionHeart Failure With Preserved Ejection Fraction

Estimated

~$10 – $8,750

35Pharma IncNCT07123779

The ACPMP Research Foundation Appendix Cancer/PMP Patient Registry

ACPMP's first-ever patient-powered global patient registry/natural history study collects patient and caregiver information and data to fuel clinical trials an…

Appendix CancerPseudomyxoma Peritonei

Estimated

~$10 – $750

Appendix Cancer Pseudomyxoma Peritonei Research FoundationNCT07769346

Phase 2

A Phase 2 Dose Optimization Trial Evaluating a CD46-Targeted Antibody-Drug Conjugate (FG-3246) in Patients With Metastatic Castration-Resistant Prostate Cancer

The purpose of this study is to evaluate the safety, efficacy, tolerability, and pharmacokinetics (PK) of FG-3246, a cluster of differentiation 46 (CD46) targe…

Metastatic Castration-Resistant Prostate Cancer

Estimated

~$10 – $7,500

Kyntra BioNCT06842498