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Virtual World-based Cardiac Rehabilitation to Improve Cardiovascular Health and Outcomes Among Cardiac Patients: A Multicenter Randomized Clinical Trial Protocol (Destination Cardiac Rehab Study)

The purpose of this research is to compare health outcomes and participation between a virtual world cardiac rehabilitation (Destination Cardiac Rehab) program…

Heart Diseases

Estimated

~$10 – $6,250

Mayo ClinicNCT07745894

Phase 4

Vaccine Responses in Patients With B Cell Malignancies

Background: People with B cell malignancies (blood cancers) often cannot mount a full immune response to infections or certain vaccines. Bruton tyrosine kinas…

Lymphoma

Estimated

~$10 – $5,625

National Heart, Lung, and Blood Institute (NHLBI)NCT05170399

Observational

Exploring the Consequences of Food Insecurity and Harnessing the Power of Peer Navigation and mHealth to Reduce Food Insecurity and Cardiometabolic Comorbidities Among Persons With HIV

The objectives of this study are to better understand how FI (food insecurities) contributes to the development of cardiometabolic comorbidities among PWH (Peo…

Food InsecuritiesCardiometabolic ComorbiditiesHIV+2 more

Estimated

~$10 – $6,250

Wake Forest University Health SciencesNCT04943861

Phase 2

A Phase 2 Pivotal Study of BCB-276, a B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma

This study will evaluate BCB-276, an investigational B7-H3-targeted Chimeric Antigen Receptor (CAR) T cell therapy, in children and young adults with diffuse i…

Diffuse Intrinsic Pontine GliomaDIPGBrain Tumor+9 more

Estimated

~$10 – $8,750

BrainChild Bio, IncNCT07680439

Observational

Circuity-guided Repetitive Transcranial Magnetic Stimulation (rTMS) for Tobacco Use in Veterans: A Comparison of Insula-rTMS and Prefrontal-rTMS

Cigarette smoking is a significant public health concern for Veterans. Encouraging smoking cessation continues to be a top priority for the Veterans' Administr…

Tabacco Use DisorderrTMS

Estimated

~$10 – $5,625

VA Office of Research and DevelopmentNCT07050862

Prospective Observational Study Using PET/MR for Characterization of Renal Masses (RMs)

The frequency of kidney tumors found incidentally on imaging studies performed for unrelated reasons continues to increase leading to more surgeries and ablati…

Renal TumorRenal Cell CarcinomaRenal Tumor, Benign

Estimated

~$10 – $750

University of Texas Southwestern Medical CenterNCT06076538

Phase 3

A Phase 3 Randomized Controlled Trial of Rondecabtagene Autoleucel , an Autologous, Dual-targeting CD19/CD20 CAR T-Cell Product Candidate, Vs. Investigator's Choice of CD19 CAR T-Cell Therapy in Patients With Relapsed or Refractory Large B-Cell Lymphoma in the Second-line Setting

This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-targeting CD19/CD20 CAR T-cell therapy, with investigator's choice of CD19 CAR T-cell…

Large B-cell LymphomaLymphoma, B-CellRelapsed Non-Hodgkin Lymphoma+6 more

Estimated

~$10 – $8,750

Lyell Immunopharma, Inc.NCT07188558

Phase 2

A Multisite, Double-blind, Randomized Controlled Trial Comparing Body Composition, Muscle, and Bone Changes to TestosteRone Therapy With or Without Finasteride After Spinal Cord Injury: TRT-SCI Trial

Spinal cord injury (SCI) results in lower limb muscle loss, bone loss, and high fat mass that impede the recovery of physical function, increase bone fracture …

Spinal Cord InjurySpinal Cord InjuriesInjuries, Spinal Cord+11 more

Estimated

~$10 – $5,625

VA Office of Research and DevelopmentNCT07742553

Point-of-Care Ophthalmic Diagnostic Imaging of Retinopathy of Prematurity

The goal of this proposal is to develop novel HH-SECTR technology for visualizing and quantifying diagnostic disease features in prematurely born infant retino…

Retinopathy of Prematurity (ROP)ROP Examination

Estimated

~$10 – $750

Vanderbilt University Medical CenterNCT06612541

Phase 4

INSIGHT-IBD Pragmatic Study: Investigation of Mirikizumab in Real World Settings for Mirikizumab

The goal of this study is to evaluate the real-world effectiveness of treatments for inflammatory bowel disease (IBD) within routine clinical practice. The st…

Ulcerative Colitis (UC)Crohn Disease (CD)

Estimated

~$10 – $7,500

Specialty Networks Research.NCT07686757

Phase 3

A Parallel-group Treatment, Phase 3, Double-blind, Randomized, 2-arm Study to Investigate the Efficacy and Safety of Apraglutide Compared With Placebo in Adult Participants With Short Bowel Syndrome Associated With Intestinal Failure (SBS-IF)

This Phase 3 placebo-controlled study is planned to further investigate the efficacy, safety, and tolerability of apraglutide in the overall SBS-IF (short bowe…

Short Bowel Syndrome (SBS)SBS Associated With Intestinal Failure (SBS-IF)

Estimated

~$10 – $8,750

VectivBio AGNCT07742735

Prospective Evaluation of Pathways for Preterm Birth: The PEPP Study

This is a single center, prospective cohort study of pregnant patients at high risk for spontaneous preterm birth: patient's with history of spontaneous preter…

Preterm BirthCervix; Pregnancy

Estimated

~$10 – $1,125

John O'Brien, MDNCT05246579