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Imaging Biomarkers of Freezing of Gait Response to Deep Brain Stimulation
For this study, the investigators are recruiting 54 individuals with Parkinson's Disease and Freezing of Gait (FOG) who are planning to undergo Deep Brain Stim…
Neural Mechanisms Underlying the Benefits of Aerobic Exercise in Advanced Parkinson's Disease
This study is focused on people with Parkinson's disease who already have deep brain stimulation devices. The goal is to understand how aerobic exercise, speci…
Investigating the Increased Risk of Falls in Individuals With Parkinson's Disease Treated With Deep Brain Stimulation
The purpose of this pilot study is to assess changes in thinking and movement after deep brain stimulator implantation. The study will also examine whether the…
Personalized Memory Enhancement in Aging: Pattern-Optimized tACS With Closed-Loop Precision Modulation
This project optimizes high-resolution transcranial Alternating Current Stimulation (tACS) to improve memory in healthy older adults, advancing drug-free appro…
An Open-label Clinical Trial Investigating the Long-term Safety of Buntanetap in Treating Participants With Parkinson's Disease
This study will examine the long-term safety of buntanetap in participants with PD. This will be a 36-month open-label safety study. This study will be conduct…
Rescuing Visual Perception in Aging Adults by Restructuring the Alpha-Gamma Neural Code
Tests whether age-related visual deficits arise from disrupted alpha-gamma coupling in visual cortex (V1) and MT. Uses fMRI, source-resolved HD-EEG, and person…
Tractography Guided Subcallosal Cingulate Deep Brain Stimulation for Treatment Resistant Depression
Treatment resistant depression remains a major problem for individuals and society. Surgical procedures may provide relief for some of these patients. The most…
Safety and Tolerability of Patterned Stimulation for DBS in the Home Setting
The primary objective of the proposed pilot study is to assess the safety and tolerability of active patterned Deep Brain Stimulation (pDBS) when administered …
Quantifying Motor Network Dynamics to Predict and Enhance Outcomes in Pediatric Dystonia
The goal of this study is to understand the development and progression of childhood dystonia, a movement disorder, in children. The main questions it aims to …
Neural Mechanisms of Interpersonal Expectations on Negative Affect
The goal of this clinical trial is to learn whether non-invasive brain stimulation, called transcranial temporal interference stimulation (tTIS), can reduce ne…
Understanding Motivation in Parkinson's Patients Through Neurophysiology
The study aims to better understand motivation and value-based decision-making in Parkinson's patients through neurophysiology using Medtronic's Percept DBS de…
Evaluation of 3 Patterned rTMS Stimulation Dosage on Corticospinal Excitability and Motor Learning in Stroke Patients
The study is about using a brain stimulation technique called rTMS (Repetitive Transcranial Magnetic Stimulation) to help improve hand muscles in people who ha…