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A Randomized, Placebo-controlled, Phase I/II Clinical Trial to Evaluate the Safety, Immunogenicity, and Impact on Virological Control of the Investigational RNA-based Vaccine BNT168 in Adults Living With or Without HIV

This study will test a new ribonucleic acid (RNA)-based vaccine called BNT168 in adults living both with and without human immunodeficiency virus (HIV), to see…

HIV -1 Infection

Estimated

~$10 – $7,500

BioNTech SENCT07698600

Evaluation of Lacrifill™ Canalicular Filler for Optimization of Ocular Surface Parameters and Biometric Precision in Prospective Cataract Surgery Patients With Dry Eye Disease

This is a single-site observational study designed to evaluate the efficacy of Lacrifill™ canalicular filler in optimizing ocular surface parameters and biomet…

Cataract

Estimated

~$10 – $1,125

The Eye Institute of West FloridaNCT07648095

Observational

Effects of Dry Needling on Quadriceps Muscle Strength in Acute Post-Operative Anterior Cruciate Ligament Reconstruction With Quadriceps Autograft in the Pediatric Population

Dry needling is a skilled intervention provided by trained physical therapists to treat pain, myofascial dysfunction, and a variety of other diagnosis. While t…

Anterior Cruciate Ligament Reconstruction RehabilitationDry NeedlingStrength

Estimated

~$10 – $6,250

Children's Mercy Hospital Kansas CityNCT07657195

A Natural History of Cardiometabolic Disease Among US Bhutanese: Developing the Bhutanese Community of Central Ohio Health Study to Identify Synergizing Socioenvironmental and Biobehavioral Risk Factors Propagating Health Disparities From a Cross-Sectional Study

Background: As of 2021, almost 45 million people in the United States were foreign-born immigrants. South Asians, including people from Bhutan, are the fastes…

Cardiometabolic Risk FactorsMental Health

Estimated

~$10 – $675

National Institute of Environmental Health Sciences (NIEHS)NCT06991751

Phase 2

A Phase II Study of Combination Bevacizumab and PRGN-2012 in Adults With Recurrent Respiratory Papillomatosis (RRP)

Background: Recurrent respiratory papillomatosis (RRP) is a rare disease that causes wart-like growths called papillomas to grow in the airway, most often in …

Respiratory Recurrent Papillomatosis (RRP)Human Papillomavirus (HPV)Papillomavirus Infection+3 more

Estimated

~$10 – $5,625

National Cancer Institute (NCI)NCT07756840

Phase 1

A Phase 1a/b Multicenter, Open-Label Trial to Evaluate Safety, Tolerability, and Dosimetry of LY4257496, a GRPR-Targeted Radioligand Therapy, in Adults With GRPR-Positive Advanced Solid Tumors (OMNIRAY)

The main purpose of this study is to evaluate safety, tolerability, and efficacy of LY4257496 alone and as part of relevant standard of care (SOC) combination …

Breast NeoplasmsColorectal NeoplasmsProstate Neoplasm+4 more

Estimated

~$10 – $7,500

Eli Lilly and CompanyNCT07114601

Augmenting Parent Management Training With Naturalistic Skills for Child Temper Outbursts Using a Digital Tool

Background: Pediatric disruptive behavior disorders (DBDs) are characterized by severe irritability, anger, and temper outbursts. The primary way to treat chi…

Disruptive Behavior DisordersConduct DisorderOppositional Defiant Disorder+1 more

Estimated

~$10 – $675

National Institute of Mental Health (NIMH)NCT07764536

Observational

VR-Enhanced BA for Older Adults With Major Depressive Disorder

The primary aims of this study are to assess the feasibility, acceptability, and tolerability of using an immersive virtual reality (VR) headset to engage in b…

Depression - Major Depressive DisorderOlder Adults (65 Years and Older)Behavioral Activation Treatment+1 more

Estimated

~$10 – $6,250

Stanford UniversityNCT07188623

Observational

Pilot Trial of the Vibrant Capsule for Spinal Cord Injury Neurogenic Bowel Dysfunction

The goal of this study is to test the safety and effectiveness of Vibrant capsules in spinal cord injury patients with neurogenic bowel.

Neurogenic Bowel DysfunctionSpinal Cord Injury

Estimated

~$10 – $6,250

The University of Texas Health Science Center, HoustonNCT07213986

Phase 1

A Phase I Trial of TOR-582, a Topical Sirolimus-based Treatment for Epistaxis in Adults With Hereditary Hemorrhagic Telangiectasia

People with hereditary hemorrhagic telangiectasia (HHT) often experience frequent and severe nosebleeds that can disrupt daily life and lead to anemia, medical…

Hereditary Hemorrhagic Telangiectasia (HHT)Epistaxis

Estimated

~$10 – $6,250

Columbia UniversityNCT07667413

Phase 3

Phase 3 Multicenter, Randomized, Open-label, Active-controlled Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb for Treatment-naïve Subjects With Metastatic Colorectal Cancer With KRAS p.G12C Mutation (CodeBreaK 301)

The aim of this study is to compare progression free survival (PFS) in treatment-naïve participants with KRAS p.G12C mutated metastatic colorectal cancer (mCRC…

Metastatic Colorectal Cancer

Estimated

~$10 – $7,500

AmgenNCT06252649

HOPE in Action Liver Transplantation From Donors With HIV: Impact on Opportunistic Infections, Cancer, and Long-Term Outcomes (Expanding HOPE Liver) (RTB-024)

This is a prospective, multicenter clinical study. The objective is to determine whether a liver transplant from a deceased donor with HIV is associated with a…

HIV InfectionLiver Transplant

Estimated

~$10 – $675

National Institute of Allergy and Infectious Diseases (NIAID)NCT07778459