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7 recruiting studies matching your filters

A Phase 2, Multicenter, Open-Label Study to Assess the Pharmacodynamics, Safety, and Tolerability of DT-168 Ophthalmic Solution in Patients With Fuchs Endothelial Corneal Dystrophy Undergoing Keratoplasty

The purpose of this study is to evaluate the pharmacodynamics, safety, and tolerability of DT-168 Ophthalmic Solution in pre-keratoplasty patients with Fuchs e…

Fuchs Endothelial Corneal DystrophyFuchs

Estimated

~$10 – $8,750

Design Therapeutics, Inc.NCT07024693

Phase 1

A Multicenter, Phase I/II, Clinical Study to Evaluate the Safety, Tolerability and Efficacy of Intrastromal Injection of Genome-editing GEB-101 in Participants With TGFBI-related Corneal Dystrophy

The goal of this clinical trial is to evaluate the safety and efficacy of GEB-101 injection in subjects with TGFBI-related Corneal Dystrophy

Hereditary Corneal DystrophyCorneal AbnormalityCorneal Dystrophies+1 more

Estimated

~$10 – $8,750

GenEditBio LimitedNCT07750678

Phase 2

Targeting Reactive Oxygen Species Production as a Novel Therapeutic in Fuch's Endothelial Corneal Dystrophy

This protocol will investigate whether topical application of N-acetyl cysteine (NAC) eye drops decreases oxidative stress and confers cytoprotection in patien…

Fuchs Endothelial Corneal Dystrophy

Estimated

~$10 – $7,500

Massachusetts Eye and Ear InfirmaryNCT04440280

Phase 2

A Multicenter, Randomized, Double-Masked, Placebo-Controlled Phase 2 Study of EO2002 in Participants With Corneal Edema Secondary to Corneal Endothelial Dysfunction (EMERALD)

This study will evaluate the safety and effectiveness of a single injection of EO2002 at one of two dose levels (150,000 or 500,000 magnetic human corneal endo…

Corneal EdemaFuchsFuchs Dystrophy+9 more

Estimated

~$10 – $7,500

EmmecellNCT07729137

National Ophthalmic Genotyping and Phenotyping Network, Stage 3 - Expansion of DNA and Data Repositories for Rare Inherited Ophthalmic Diseases

Background: The eyeGENE (Registered Trademark) program is a research resource for inherited eye conditions which includes genotypic and phenotypic data, imagi…

Inherited Ophthalmic DiseasesHypopigmentation DisorderCorneal Dystrophy+4 more

Estimated

~$10 – $675

National Eye Institute (NEI)NCT06491615

Optical Coherence Tomography-Aided Differential Diagnosis and Treatment of Irregular Corneas

This main goal of this study is to improve the detection, classification, monitoring, and treatment of irregular corneas due to keratoconus, warpage, dry eye, …

KeratoconusCorneal OpacityCorneal Dystrophy

Estimated

~$10 – $750

Oregon Health and Science UniversityNCT03504800

Coordination of Rare Diseases at Sanford

CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, …

Rare DisordersUndiagnosed DisordersDisorders of Unknown Prevalence+340 more