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152 recruiting studies matching your filters

Phase I/II Trial of Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate Cancer

Background: Head and neck cancers (HNCs) account for about 5% of all cancers worldwide. They grow in the mouth, throat, nasal cavity, or salivary glands. Pros…

Head and Neck CancerHead and Neck Squamous Cell CarcinomaParanasal Sinus Neoplasms+9 more

Estimated

~$10 – $5,625

National Cancer Institute (NCI)NCT07667400

Phase 1

A Phase I Randomised, Single-blind, Placebo-controlled Study to Assess the Safety, Tolerability, and Pharmacokinetics of AZD1613 Following Multiple Ascending Dose Administration in Participants With Autosomal Dominant Polycystic Kidney Disease

A study to investigate safety, tolerability, and pharmacokinetics of AZD1613 following subcutaneous or intravenous administration in participants with autosoma…

Autosomal Dominant Polycystic Kidney Disease

Estimated

~$10 – $7,500

AstraZenecaNCT07228364

Phase 2

A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study of 24 to 52 Weeks Treatment to Evaluate The Efficacy And Safety of Galvokimig in Adult Study Participants With Non-Cystic Fibrosis Bronchiectasis (ATMOS)

The purpose of the study is to investigate the efficacy of galvokimig versus placebo on the time to the first pulmonary exacerbation in study participants with…

Non-cystic Fibrosis Bronchiectasis

Estimated

~$10 – $8,750

UCB Biopharma SRLNCT07720375

Role of Genetic Factors in the Pathogenesis of Lung Disease

This study is designed to evaluate the genetics involved in the development of lung disease by surveying genes involved in the process of breathing and examini…

Cystic FibrosisPulmonary FibrosisTuberous Sclerosis+2 more

Estimated

~$10 – $675

National Heart, Lung, and Blood Institute (NHLBI)NCT00001532

Sinus Disease in Young Children With Cystic Fibrosis

This is a prospective, observational study examining the impact of highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulators on ch…

Cystic Fibrosis in ChildrenCystic FibrosisChronic Rhinosinusitis (Diagnosis)+2 more

Estimated

~$10 – $750

University of California, Los AngelesNCT06191640

The Impact of Sinus Surgery in the Era of Highly Effective Modulatory Therapy

This study will be a prospective, observational study of patients who undergo endoscopic sinus surgery for cystic fibrosis-related chronic rhinosinusitis (CRS)…

Chronic Rhinosinusitis (Diagnosis)Cystic Fibrosis

Estimated

~$10 – $750

University of California, Los AngelesNCT04469439

Phase 2

Phase II Trial of Puxitatug Samrotecan (AZD8205) in Advanced, Recurrent or Metastatic (R/M) Aggressive Adenoid Cystic Carcinoma Subtype I (ACC-I)

Phase II open label study designed to evaluate the efficacy and safety of P-Sam in patients with aggressive, solid, NOTCH mutant or p63 low (B7-H4 high) R/M AC…

Adenoid Cystic Carcinoma

Estimated

~$10 – $6,250

M.D. Anderson Cancer CenterNCT07162480

Phase 1

A Phase 1/2 Study of CB-103 (Oral Pan-NOTCH Inhibitor) With Abemaciclib or Lenvatinib in Combination in Patients With NOTCH Activated Adenoid Cystic Carcinoma (CALCulus)

The goal of this study is to treat patients with NOTCH active advanced adenoid cystic carcinoma (ACC) tumors with a combination or two different oral medicatio…

Adenoid Cystic CarcinomaMetastatic Adenoid Cystic CarcinomaRecurrent Adenoid Cystic Carcinoma

Estimated

~$10 – $7,500

Michael J. Dennis, MDNCT05774899

Phase 2

A Double-blind, Phase II Randomized Study of Brain-directed Stereotactic Radiation With or Without AGuIX Gadolinium-based Nanoparticles in the Management of Brain Metastases at Higher Risk of Local Recurrence With Radiation Alone

The purpose of this study is to determine whether AGuIX (Activation and Guidance of Irradiation by X-ray) gadolinium-based nanoparticles make radiation work mo…

Brain CancerBrain MetastasesMelanoma+13 more

Estimated

~$10 – $6,250

Brigham and Women's HospitalNCT04899908

Natural History of Treated Neurocysticercosis and Long-Term Outcomes

Neurocysticercosis is a brain disease due to the larval stage of the pork tapeworm (Taenia solium). The most common symptoms patient experience from infection …

CysticercosisNeurocysticercosis

Estimated

~$10 – $675

National Institute of Allergy and Infectious Diseases (NIAID)NCT00001205

DICER1-Related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study

Background: \- Pleuropulmonary blastoma (PPB) is a rare fast-growing lung tumor that is associated with other, rare tumor types. Most cases of PPB appear in c…

Pleuropulmonary BlastomaCystic NephromaOvarian Sertoli-Leydig Cell Tumors+2 more

Estimated

~$10 – $675

National Cancer Institute (NCI)NCT01247597

Phase 1

A Phase Ic, Open-label, Multicenter Study to Evaluate the Safety, Tolerability, and Activity of Inhaled GDC-6988 in Patients With Muco-obstructive Disease

This study evaluates the safety, tolerability, and activity of inhaled GDC-6988 in participants with muco-obstructive disease.

Non-cystic Fibrosis BronchiectasisChronic Obstructive Pulmonary Disease

Estimated

~$10 – $8,750

Genentech, Inc.NCT06603246