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Phase 1 Dose Escalation and Expansion Study of TROP2 CAR Engineered IL-15- Transduced Cord Blood-derived NK Cells in Combination With Cetuximab in Patient With Colorectal Cancer (CRC) With Minimal Residual Disease (MRD)
To find the highest and/or recommended dose of TROP2-CAR-NK cells combined with cetuximab in participants with MRD CRC.
An Open-Label, Multi-Center, Dose Escalation, Confirmation, and Expansion Phase I Clinical Study to Evaluate the Safety, Tolerability, Efficacy, and Pharmacokinetics of MRG007 (ARR-217) in Participants With Unresectable Locally Advanced or Metastatic Solid Tumors
This is an open-label, multi-center, phase I study to evaluate the safety, tolerability, efficacy, and pharmacokinetics of MRG007 (ARR-217) in patients with un…
Enhancing Team Effectiveness for a Collaborative School-based Intervention for ADHD
The proposed project aims to integrate team-based implementation strategies with an established school-based intervention for children with ADHD, the Collabora…
Achieving Steady Work Among Adults With Autism Through Specialized Employment Program
Individuals with autism spectrum disorder (ASD) have significantly higher levels of unemployment and underemployment compared to their typically developing pee…
PrEP Intervention for People Who Inject Substances and Use Methamphetamine
In this study, "PrEP Intervention for people who Inject Substances and Use Methamphetamine" (PRIME), we propose to assess if using video directly observed ther…
Animal and Plant Proteins and Glucose Metabolism
The goal of this proposal is to determine the effect of a high protein diet in which the increase in protein intake is derived from different sources (animal v…
SunBeast: Evaluating UV Protective Behaviors and Education Interventions Among Ultrarunners at the Western States Endurance Run
Participants will be randomly assigned to either the intervention or control group using concealed allocation. The intervention-comprising targeted educational…
Imaging Genetics of Laryngeal Dystonia
The contribution of genetic risk factors to the development of focal dystonias is evident. However, understanding of how variations in the causative gene expre…
To Close or Not to Close: Surgical Site Infection Rates in Ostomy Primary Closure With 0.1% Betaine/Polyhexanide Wound Irrigation Compared to Conventional Ostomy Closure by Secondary Intention
The goal of this clinical trial is to compare two types of closure in patients with ostomies that are ready for closure. The main questions it aims to answer a…
Community Partnership for Telehealth Solutions to Counter Misinformation and Achieve Equity
Non-randomized, two-arm stepped-wedge trial of a multi-level colorectal cancer screening intervention.
Visual Field Expansion Through Innovative Multi-Periscopic Prism Design
The investigators will develop and test different configurations of high-power prisms to expand the field of vision of patients with visual field loss to assis…
Phase I Trial of ZEN003694 (ZEN-3694) in Combination With Capecitabine in Patients With Solid Tumors
This phase I trial tests the safety, side effects, and best dose of ZEN003694 in combination with the usual treatment with capecitabine in treating patients wi…