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748 recruiting studies matching your filters

A Comparison of Neuromuscular Recruitment in Trained and Untrained Adults

The objective of the study is to use neurological techniques to obtain quantitative measurements of nervous system control of skeletal muscle activity in adult…

HealthyInsulin Resistance

Estimated

~$10 – $750

Mayo ClinicNCT06820658

Phase 1

Novel Biomarkers of Non-IgE Immediate Hypersensitivity Drug Reactions

The goal of this clinical trial is to investigate biomarkers of non-IgE-mediated immediate hypersensitivity reactions during infusion of intravenous vancomycin…

Healthy VolunteerHypersensitivity ReactionsVancomycin

Estimated

~$10 – $6,250

Johns Hopkins UniversityNCT07605806

Phase 1

A Clinical Study to Evaluate the Plasma Pharmacokinetics of a Single Dose of MK-4082 With and Without Diltiazem Coadministration in Healthy Participants

Researchers are looking for new weight loss medicines for people with higher body weight. The trial medicine, MK-4082, is different from similar weight loss me…

Healthy

Estimated

~$10 – $8,750

Merck Sharp & Dohme LLCNCT07697625

Observational

Families Implementing Good Health Traditions for Life

This study will provide evidence for the utility of using a community-engaged research approach to implement a tailored, family-oriented adaptation of the Diab…

DiabetesChronic DiseaseType 2 Diabetes+6 more

Estimated

~$10 – $6,250

Morehouse School of MedicineNCT07441655

The Relationship Between Neurostimulation Intensity and Pupillary Dilation Reflex (PRD) in Healthy Volunteers

This a single site, observational study that will examine how the pupil responds to neurostimulation under different conditions in healthy adults. The objectiv…

Healthy Participants

Estimated

~$10 – $675

Children's National Research InstituteNCT07746167

Phase 1

A First-in-Human, Phase 1, Randomized, Double-Blinded, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of ABBV-859 After Single Ascending Doses in Healthy Adult Subjects

The objective of this study is to assess the pharmacokinetic (PK), immunogenicity, safety, and tolerability of ABBV-859 after single ascending doses in healthy…

Clinical Research Consortium for the Study of Cerebellar Ataxias (CRC-SCA) for the Natural History Study of and Genetic Modifiers in Spinocerebellar Ataxias (SCA)

Spinocerebellar ataxias (SCA) are genetic neurological diseases that cause imbalance, poor coordination, and speech difficulties. There are different kinds of …

Spinocerebellar Ataxia Type 1Spinocerebellar Ataxia Type 2Spinocerebellar Ataxia Type 3+7 more

Estimated

~$10 – $1,125

Lauren MooreNCT01060371

Phase 1

A Phase I, Randomized, Single-blind, Placebo-controlled Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD3974 After Single and Multiple Ascending Dosing to Healthy Participants

The purpose of this study is to assess the safety and tolerability of AZD3974 and characterize the pharmacokinetics (PK) of AZD3974 following oral administrati…

Healthy Participants

Estimated

~$10 – $7,500

AstraZenecaNCT07290283

Phase 1

An Open-label, Positron Emission Tomography Study to Evaluate Brain Receptor Occupancy, Safety, Tolerability, and Pharmacokinetics After a Single Sublingual Administration of ITI-1284 in Healthy Subjects

The study will be conducted as an open-label and single-center study to evaluate the occupancy of ITI-1284 to the dopamine D2 receptor, serotonin 2A (5-HT2A) r…

Healthy Volunteers

Estimated

~$10 – $8,750

Intra-Cellular Therapies, Inc.NCT06299410

Phase 1

Effects of Sirolimus on Middle Aged Asymptomatic ApoE4 Carriers

Alzheimer's disease is a devastating neurodegenerative disease characterized by accumulation of clumps (also called plaques) and bundles of fibers (also called…

Genetic Predisposition to DiseaseHealthy VolunteerAPOE-4 Positive

Estimated

~$10 – $6,250

University of Missouri-ColumbiaNCT07728175

Phase 1

A Phase 1, Randomized, Investigator- and Participant-Blinded, Placebo-Controlled, Single- and Multiple-Ascending Dose Study to Characterize the Safety, Tolerability, and Pharmacokinetics of LY4515100 in Healthy Participants and an Open-Label Study to Evaluate the Effect of Itraconazole on the Pharmacokinetics, Safety, and Tolerability of LY4515100 and of LY4515100 on the Pharmacokinetics of CYP and Transporter Substrates in Healthy Participants

The main purpose of this study is to assess the safety and tolerability of LY4515100 when given orally to healthy participants. LY4515100 will be given by itse…

Healthy

Estimated

~$10 – $7,500

Eli Lilly and CompanyNCT07339722

Signature Development and Validation Protocol for an Epigenetic Assay in Diagnosing Lung Cancer

The purpose of this research study is to test a new process for diagnosing lung cancer by examining changes to your DNA that can be detected from a blood test.…

Lung CancerLung Cancer ScreeningHealthy Volunteers (HV)+1 more

Estimated

~$10 – $750

University of Maryland, BaltimoreNCT07008664