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Community Health Adaptation & Resilience Mobilization (CHARM) Lake County
Extreme heat events pose serious health risks, especially for communities with limited access to cooling, transportation, or social support. This study pilots …
Exploring a Common Genetic Risk Factor for Heat Stroke and Dehydration
The goal of this observational study is to examine the effect of the Cystic Fibrosis (CF) Carrier state on the risk for dehydration and other CF-specific fluid…
Predicting Responses to Exhausting, Prolonged, And Repeated Exercise Demands (PREPARED) for Heat
The overall goal of this project is to identify a work/rest cycle that allows for faster mission completion needed in emergency situations, compared to current…
Multi-Institutional Registry for Malignant Peripheral Nerve Sheath Tumors
First, the investigators plan to use a retrospective analysis to determine the clinical landscape of neurofibromatosis (NF)1-associated malignant peripheral ne…
Aging, Beta Blockers, and Thermoregulatory Responses
This study will test the hypothesis that the drugs propranolol and metoprolol will result in greater increases in core body temperature during 3 hours of extre…
Beat the Heat: Impacts of Heat on Health in Boston and Strategies to Address Them
The goal of this stepped wedge trial is to assess the practical effects of air conditioners on hot weather impacts among older adults. The main questions it ai…
A Multi-Center Phase II Study of Selinexor in Treating Recurrent or Refractory Wilms Tumor and Other Pediatric Solid Tumors
The purpose of this study is to find out whether selinexor is an effective treatment for people who have a relapsed/refractory Wilms tumor, rhabdoid tumor, MPN…
Principle Investigator
The investigators would like to see if the combination of TENS and controlled heat in a boot increases blood flow to the foot more than baseline or heat alone …
Does Heat Stress Improve the Acute Metabolic and Cardiovascular Adaptations to Exercise
Life in space is completely void of physical and environmental stress. It is well known that living things need regular physical stress (e.g. exercise) to rema…
A Phase 1 Multiple Expansion Cohort Trial of MRTX1719 in Patients With Advanced Solid Tumors With Homozygous MTAP Deletion
This is a Phase 1, open-label, multicenter, study of the safety, tolerability, PK, PD, and anti-tumor activity of MRTX1719 patients with advanced, unresectable…
A Phase II Study of ASTX727 in Patients With PRC2 Loss Malignant Peripheral Nerve Sheath Tumor (MPNST)
The purpose of this study is to see whether the study drug ASTX727 is an effective treatment for people who have MPNST with a PCR2 mutation. ASTX727 is a comb…
Effects of Creatine Supplementation on Cognitive Measures and Markers of Acute Kidney Injury After Exercise in the Heat
The goal of this clinical trial is to learn if one week of creatine monohydrate supplementation alters inflammation, markers of acute kidney injury (AKI) risk,…