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Using Novel Labeling to Improve Public Understanding of Nicotine in Electronic Nicotine Delivery Systems (ENDS): Nicotine Concentration and Nicotine Flux
Current labels for the nicotine in e-cigarette/vaping products do not sufficiently convey information to the public. The aims of this study include developing …
Pharmacological Effects of Cannabidiol on Responses to Stress and Nicotine Withdrawal
The purpose of this study is to examine the effect of doses of cannabidiol (CBD) during exposure to stress and nicotine withdrawal in nicotine users. The main …
Orexin's Role in The Neurobiology of Substance Use Disorder
Study Description: Despite the availability of pharmacotherapy for some substance use disorders, relapse vulnerability is still a significant issue. This sugg…
AI-Enhanced App-based Intervention for Adolescent E-cigarette Cessation
The goal of this quasi-experimental study is to test if a smartphone app can help adolescents aged 14-20 quit e-cigarettes. The main questions it aims to answe…
Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging
Background: \- Functional and structural magnetic resonance imaging (MRI) techniques have allowed researchers to map and study how the brain works when at res…
Vaping Cessation Among Youth: Evaluating the Kick-Nic! App
High school and middle school students who want to quit vaping will be randomized to receive the Kick-Nic! app or a control NCI website to determine the effica…
ACT on Vaping: Digital Therapeutic for Young Adult Vaping Cessation
This clinical trial evaluates a smartphone application (app) called Acceptance and Commitment Therapy (ACT) on Vaping for helping young adults quit using elect…
Social Media Support Groups for Adolescent Vaping Cessation
The purpose of this study is to pilot test feasibility and acceptability of the Quit the Hit Toolkit, a social media-based nicotine vaping cessation program fo…
Sex Differences in E-Cigarette Perception: Study 2
This study examines differences between males and females in the appeal and addiction potential of menthol flavored e-cigarettes with and without nicotine.
Temporal Interference Methods for Addiction Treatment
This clinical study is testing whether a new non-invasive brain stimulation method, called temporal interference (TI), can reduce nicotine cravings and usage i…
Cue-Exposure Response Evaluation: Brain Reactivity to ONPs
Oral nicotine pouches (ONPs) are non-combustible nicotine products that may reduce cigarette craving and smoking cue-induced brain activity, supporting their p…
Evaluation of Varenicline and Accelerated TMS for Reduction of Nicotine Use
The goal of this clinical trial is to learn if a combination of varenicline and enhanced accelerated Transcranial Magnetic Stimulation (aTMS) works to help adu…