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A Phase 1 Pharmacokinetic, Dosimetry, Safety, and Dose Optimization Study for a Single Dose of TLX090-Tx (153SmDOTMP) to Treat Metastatic Bone Pain
This is an open label, 2-part early phase study designed to evaluate the safety, pharmacokinetics, radiation dosimetry, and preliminary efficacy of TLX090-Tx i…
Empowered Relief for Caregivers (ER-CY): A Co-Designed Brief Intervention to Support Families of Youth With Chronic Pain
This study is testing a new program called Empowered Relief for Caregivers (ER-CY), designed to support caregivers of children and teens who live with chronic …
Study of Low-intensity Focused Ultrasound Effects on Heat Evoked fMRI Signals
Study of LIFU on fMRI pain signals. Participants receive low-intensity focused ultrasound (LIFU) and fMRI scans to measure changes in both resting and heat pai…
Pain Outcomes Associated With Exogenous Hormone Therapy in Adults
TRANSPIRE is an observational study of \~200 individuals who (1) will be initiating gender-affirming hormone therapy (GHT) or (2) are gender minority individua…
Active vs. Passive Virtual Reality for Reducing Pain and Anxiety During Office-based ENT Procedures
The purpose of this research is to evaluate whether active virtual reality reduces pain and anxiety more effectively than passive virtual reality during office…
Virtual Intelligence for Transformative Lifestyle Solutions in Pain
This pilot study aims to evaluate the feasibility and acceptability of a VR-based chronic pain management intervention with a virtual AI coach for patients wit…
Strength and Pain-Coping Through Resilience and Knowledge
Older adults who are 50 years of age and older with depressive symptoms, pain and difficulty with mobility will participate in the SPARK intervention study tha…
Randomized, Placebo-Controlled, Phase 2 Clinical Trial to Evaluate LY4065967 for the Treatment of Osteoarthritis
The main purpose of this study is to test the safety and efficacy of study drug for the treatment of knee pain due to osteoarthritis (OA). This trial is part o…
Mechanisms of Mindfulness Meditation and Self-Hypnosis for Pain in Older Adults With Chronic Pain
The goal of this study is to better understand how two common psychological treatments for pain work in the brain of older adults living with chronic pain. Thi…
Psychophysical Studies of Cancer Therapy-Induced Pain: A Feasibility Study
The Aim of this Study is to examine the feasibility of using quantitative sensory testing procedures, widely applied to the experimental study of sensory proce…
Intranasal and Intravenous Oxytocin for Analgesia to Noxious Heat Pain
The goal of this research study is to find out how well oxytocin works to reduce pain. Oxytocin will be given intravenously (IV) and as a nasal spray. The stud…
"Impact of an Educational Podcast for Patients With Chronic Pelvic Pain"
The purpose of this research study is to study the impact of an educational podcast on pelvic pain. If you decide to take part in this research, you may receiv…