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Study of Fetal Health Outcomes: Working With a Missouri E-telehealth Platform
The goal of this clinical trial is to evaluate the potential benefit to patients and providers from using the remote fetal-monitoring system NUVO along with it…
Postpartum Evaluation of Antihypertensives for Control of Hypertension: A Randomized Controlled Equivalence Study
This is an open label, randomized controlled trial designed to compare nifedipine and enalapril in the management of postpartum hypertension. This is an equiva…
Fetal Electrophysiologic Abnormalities in High-risk Pregnancies Associated With Fetal Demise
Each year world-wide, 2.5 million fetuses die unexpectedly in the last half of pregnancy, 25,000 in the United States, making fetal demise ten-times more commo…
Maternal and Postnatal Outcomes Study (MOS) A Worldwide Decentralized Observational Registry to Evaluate the Safety in Women With Fabry Disease and Their Infants Exposed to Elfabrio® (Pegunigalsidase Alfa-iwxj/Pegunigalsidase Alfa) During Pregnancy and/or Lactation
The goal of this observational registry is to evaluate the safety and outcomes of pregnancy and lactation in women with Fabry disease who are exposed to peguni…
Examining the Gastric Emptying Halftime of Water Versus a Carbohydrate in Early Labor
To determine the half time of the emptying of the stomach of women in early labor with and without epidural pain relief when drinking either water or a carbohy…
Antenatal Factors Impacting Obesity and Metabolism in Children: Sub-objective 2D
The Expecting intervention as delivered in prior studies in a clinical setting is described in a previous approved IRB submission (Protocol 202954). The curren…
Determination of the 90% Effective Volume (ED90) of Epidural 0.1% Ropivacaine and Fentanyl for Labor Analgesia Initiation in Patients Receiving a Dural-Puncture Epidural Technique
This study is being done to determine the most effective dose of medicine to use to initially provide effective pain relief within the first 30 minutes of rece…
Preliminary Studies on Implementation of Smoking Cessation Interventions for Low-Income Women
This study is a preliminary evaluation of a smoking cessation intervention designed for pregnant women that combines text message support and financial incenti…
The Effect of Antibiotics on Latency in Previable Prelabor Rupture of Membranes Between 18 0/7 and 22 6/7 Weeks Gestational Age
This study is a non-blinded, prospective, randomized controlled trial designed to compare the effect of outpatient oral antibiotics (i.e., amoxicillin and azit…
Optimizing Cardiovascular Preventive Care for Women Following Hypertensive Disorders of Pregnancy
Cardiovascular disease is the leading cause of death among women in the United States, and women with hypertensive disorders of pregnancy have a 2-fold higher …
The Impact of COVID-19 on Maternal and Neonatal Outcomes
The novel coronavirus (SARS-CoV-2) infection (COVID-19) has caused a worldwide pandemic. There is still much that is unknown regarding the virus, especially it…
PRenatal and Obstetric Maternal Exposures and ISlet Autoantibodies in Early Life
This research study is called 'PRenatal and Obstetric Maternal Exposures and ISlet Autoantibodies in Early Life: The PROMISE Study'. The purpose of this study …