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116 recruiting studies matching your filters

Phase 1/2 Study Evaluating the Safety and Efficacy of Gene Therapy Employing Lentiviral Vector ALS20-transduced Hematopoietic Progenitor Cells in Subjects With Transfusion-dependent-thalassemia

The main goal of this study is to find out if the blood disorder called transfusion-dependent beta thalassemia can be safely treated by modifying blood stem ce…

Beta-Thalassemia

Estimated

~$10 – $6,250

Children's Hospital of PhiladelphiaNCT06364774

Phase 2

Psilocybin in the Treatment of Methamphetamine Use Disorder

This trial tests whether psilocybin-assisted treatment can help adults stop using methamphetamine. Participants receive a single oral dose of psilocybin during…

Methamphetamine Use Disorder

Estimated

~$10 – $7,500

Peter HendricksNCT07774702

Phase 3

An Open-label, Multi-centre, Rollover Study to Characterise Long-term Safety and Efficacy of Etavopivat in Adults, Adolescents and Children Who Have Sickle Cell Disease or Thalassaemia and Have Completed a Treatment Period in an Etavopivat Study

Etavopivat is a new medicine under development for treating blood disorders like sickle cell disease and thalassaemia. Sickle cell disease and thalassaemia are…

Sickle Cell DiseaseThalassemia

Estimated

~$10 – $7,500

Novo Nordisk A/SNCT06609226

Phase 2

Safety and Efficacy of Intracameral Zimoxin (0.1% Moxifloxacin Solution) for Prevention of Endophthalmitis After Cataract Surgery

Intracameral injection of 0.1% moxifloxacin solution after cataract surgery to prevent endophthalmitis

Endophthalmitis

Estimated

~$10 – $7,500

Jason Ahee, M.D.NCT03244072

Phase 1

Open-Label Phase 2 Trial of Vyxeos in Patients With Intermediate and High-Risk Acute Myeloid Leukemia Who Have Failed an Initial Cycle of Standard Cytarabine and Daunorubicin Chemotherapy

This phase II trial studies the side effects and how well Vyxeos works in treating patients with intermediate and high-risk acute myeloid leukemia who have fai…

Blasts More Than 5 Percent of Bone Marrow Nucleated CellsPersistent DiseaseRefractory Acute Myeloid Leukemia

Estimated

~$10 – $6,250

Ohio State University Comprehensive Cancer CenterNCT04049539

Observational

Efficacy of Self-Administered Percussive Massage Therapy Versus Gentle Manual Massage to the Thigh Following Anterior Total Hip Arthroplasty: A Prospective Randomized Controlled Trial

Many people who have hip replacement surgery through a "bikini incision" on the front of the hip (anterior approach) develop numbness, tingling, burning, or ti…

ParesthesiaTotal Hip Arthroplasty (THA)Direct Anterior Total Hip Arthroplasty+1 more

Estimated

~$10 – $7,500

Zachary M RicciardelliNCT07790705

Observational

Localized Mammary Alcohol Metabolism as a Mechanism Linking Low-Level Alcohol Intake to Breast Cancer Risk

Alcohol consumption, even at low levels, has been associated with increased breast cancer risk, but the biological mechanisms underlying this relationship rema…

Alcohol DrinkingEthanol IntoxicationBreastfeeding

Estimated

~$10 – $6,250

University of Illinois at Urbana-ChampaignNCT07779967

Phase 1

Matched Related Donor Non-myeloablative Hematopoietic Cell Transplantation With Alemtuzumab, 400 cGy TBI, and Abatacept for Sickle Cell Disease and Beta-Thalassemia

This is a non-ablative (partial) stem cell transplant for patients with severe sickle cell disease or beta-thalassemia requiring red cell transfusions. The int…

Sickle Cell DiseaseBeta-thalassemia

Estimated

~$10 – $5,625

National Heart, Lung, and Blood Institute (NHLBI)NCT07599176

International Rapid-onset Obesity With Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD) REDCap Registry

The Center for Autonomic Medicine in Pediatrics (CAMP) has collaborated with doctors from around the world to build the first International ROHHAD (Rapid-onset…

ROHHADRapid-Onset Obesity With Hypothalamic Dysfunction, Hypoventilation & Autonomic Dysregulation

Estimated

~$10 – $1,125

Ilya KhaytinNCT03135730

International Prospective Registry of Patients With Alpha Thalassemia

This is an international prospective registry of patients with Alpha thalassemia to understand the natural history of the disease and the outcomes of fetal the…

Alpha-ThalassemiaAlpha Thalassemia MajorAlpha Thalassemia Minor

Estimated

~$10 – $675

University of California, San FranciscoNCT04872179

Phase 1

Buprenorphine for the Management of Pain in Children With Sickle Cell Disease

The goal of this clinical trial is to learn whether a single dose of buccal buprenorphine (BELBUCA) is safe when used in place and/or with full agonist opioids…

Sickle Cell Disease (SCD)Sickle Cell Disease Vaso-occlusive CrisisSickle Cell Anemia Crisis+4 more

Estimated

~$10 – $7,500

Natasha ArcherNCT07799571

UCSF Center for Genome Surgery Biobank and Registry

Gene editing approaches (including but not limited to: CRISPR, LNP, AAV, RNAi etc.) for the medical specialty of interventional genomics require (1) determinat…

Any Conditions That Are Genetic or Suspected to be Genetic in Origin

Estimated

~$10 – $675

University of California, San FranciscoNCT07396285