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A Phase 2, Multicenter, Randomized, Double-Blind, Parallel-Arm Study to Investigate the Efficacy and Safety of Adjunctive Treatment With Brenipatide in Delaying Time to Relapse Compared With Placebo in Adult Participants With Bipolar Disorder (RENEW-Bipolar-1)

The purpose of this study is to assess the efficacy and safety of brenipatide when administered with standard of care (SoC), compared with placebo plus SoC in …

Bipolar Disorder

Estimated

~$10 – $7,500

Eli Lilly and CompanyNCT07286175

Observational

Our Peers - Empowerment and Navigational Support - Community Living (OP-ENS - CL)

The goal of this clinical trial is to learn if a remote peer navigator intervention (OP-ENS - CL) for people with newly acquired physical disabilities returnin…

Disabled Persons

Estimated

~$10 – $8,750

Susan MagasiNCT06941233

Phase 3

Phase 3 Multicenter, Randomized, Open-label, Active-controlled Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb for Treatment-naïve Subjects With Metastatic Colorectal Cancer With KRAS p.G12C Mutation (CodeBreaK 301)

The aim of this study is to compare progression free survival (PFS) in treatment-naïve participants with KRAS p.G12C mutated metastatic colorectal cancer (mCRC…

Metastatic Colorectal Cancer

Estimated

~$10 – $7,500

AmgenNCT06252649

Olfactory Function and Model-based Behavior in People Living With HIV and SUD

Background: Human immunodeficiency virus (HIV) infection can affect areas of the brain that control thinking ability. These same areas of the brain also contr…

HIVSubstance Use Disorder

Estimated

~$10 – $675

National Institute on Drug Abuse (NIDA)NCT07637669

HOPE in Action Liver Transplantation From Donors With HIV: Impact on Opportunistic Infections, Cancer, and Long-Term Outcomes (Expanding HOPE Liver) (RTB-024)

This is a prospective, multicenter clinical study. The objective is to determine whether a liver transplant from a deceased donor with HIV is associated with a…

HIV InfectionLiver Transplant

Estimated

~$10 – $675

National Institute of Allergy and Infectious Diseases (NIAID)NCT07778459

Observational

Coaching and Leadership in Autism Support Settings

Schools serve a large number of autistic children, yet face two critical gaps that stifle the delivery of evidence-based practices: 1) an intervention gap char…

Autism Spectrum Disorder (ASD)

Estimated

~$10 – $6,250

University of California, Los AngelesNCT07276750

Phase 3

A Phase 3, Multi-Center Study to Evaluate the Pharmacokinetics, Efficacy, and Safety of Risankizumab With Open-Label Induction, Randomized Double-Blind Maintenance, and Open-Label Long-Term Extension Periods in Pediatric Subjects (2 to < 18 Years of Age) With Moderately to Severely Active Ulcerative Colitis

Ulcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and bleeding from the lining of the rectum and colon (large intestine)…

A Phase 1/2, Open-Label, Multi-Center, Dose Escalation, Dose Expansion, and Single Repeat Dose Study of TSRA-196 in Adults With the PiZZ Genotype Who Have Lung and/or Liver Disease Associated With Severe Alpha-1 Antitrypsin Deficiency

This is a Phase 1/2, open-label, multi-center, dose escalation (Part 1), dose expansion (Part 2), and single repeat dose (Part 3) study to evaluate the safety,…

Alpha-1 Antitrypsin Deficiency (AATD)

Estimated

~$10 – $8,750

Tessera Therapeutics, Inc.NCT07227207

Sample Collection Study to Analyze Cerebral Spinal Fluid as a Biomarker for Brain Metastasis in Metastatic Breast Cancer

Background: Breast cancer is the most common cancer among women. It can often spread to the liver, lungs, bones, or brain. Breast cancer that spreads to the b…

Breast CancerBreast CarcinomaCancer of the Breast+1 more

Estimated

~$10 – $675

National Cancer Institute (NCI)NCT07619534

Phase 1

A Phase 1b Study Evaluating Combinations With PSCA-Targeting Chimeric Antigen Receptor (CAR)-T Cells for Patients With PSCA+ Metastatic Castration-Resistant Prostate Cancer

This phase Ib trial tests the safety, side effects, and best dose of autologous anti-prostate stem cell antigen (PSCA)-chimeric antigen receptor (CAR)-4-1BB/TC…

Castration-Resistant Prostate CarcinomaMetastatic Prostate CarcinomaStage IVB Prostate Cancer AJCC v8

Estimated

~$10 – $6,250

City of Hope Medical CenterNCT05805371

Observational

Controller Development to Enable Individualized Assistance in Robotic Ankle Exoskeletons

This study is developing and testing a new controller for a robotic ankle exoskeleton (Biomotum) that can adjust itself in real time to better support people w…

Healthy Young Adults

Estimated

~$10 – $6,250

University of NebraskaNCT07393971

Phase 2

A Randomized, Multicenter, Double-Blind, Parallel, Placebo-controlled Phase 2b Clinical Trial to Evaluate the Efficacy and Safety of YN001 in Adults With Coronary Atherosclerosis

This study is designed to evaluate the efficacy and safety of intravenously administered YN001 in patients diagnosed with coronary atherosclerosis, who are rec…

AtherosclerosisCoronary Artery Disease

Estimated

~$10 – $8,750

Beijing Inno Medicine Co., Ltd.NCT07521007