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189 recruiting studies matching your filters

Neural Circuit-Specific Mechanisms of Ketamine's Effect on Anhedonia and Anxiety in Depression Using Ultra-High Field 7-Tesla MRI

This project is designed to examine the role of the subgenual anterior cingulate cortex (sgACC) in anhedonia and anxiety in humans with depression, as well as …

Major Depressive Disorder

Estimated

~$10 – $6,250

Icahn School of Medicine at Mount SinaiNCT06213324

Evaluating Integrated Care and Wearable Technology Outcomes in the Shields & Stripes Program for Veterans and First Responders: A Retrospective Mixed-Methods Study

This study aims to evaluate outcomes from the Shields \& Stripes (S\&S) program - a 12-week, multidisciplinary wellness intervention designed for veterans and …

Holistic CareMental HealthSleep+9 more

Estimated

~$10 – $750

Baylor UniversityNCT07452900

Observational

Developing Rumination-focused Treatment to Reduce Risk for Depression Recurrence (RDR) in Adolescence

This study will evaluate whether a newer treatment, rumination-focused cognitive behavioral treatment, which includes mindfulness and can be used to reduce rum…

Major Depressive DisorderMood Disorders

Estimated

~$10 – $6,250

Ohio State UniversityNCT03859297

Observational

Integration of a Behavioral Health Collaborative Care Model Into an ICU Recovery Clinic-Pilot for Families

This pilot study evaluates the feasibility and acceptability of implementing a Behavioral Health Collaborative Care Model (BH CoCM) for family members of ICU s…

Critical Illness RecoveryBehavioral Health ConcernsAnxiety+4 more

Estimated

~$10 – $6,250

Medical University of South CarolinaNCT07390786

Observational

Pilot Study Using Endogenous Aperiodic Brain Activity to Personalize Transcranial Alternating Current Stimulation as a Treatment for Antenatal Depression: PandA-tACS

The purpose of this study is to develop the safety, feasibility, and tolerability of a personalized transcranial alternating current stimulation (tACS) approac…

Antenatal DepressionMajor Depressive DisorderMajor Depressive Disorder in Pregnancy+1 more

Estimated

~$10 – $6,250

University of North Carolina, Chapel HillNCT06979154

University of Iowa Interventional Psychiatry Service Patient Registry

The purpose of this study is to examine the effects of interventional/procedural therapies for treatment-resistant depression (TRD) and Obsessive-Compulsive Di…

Treatment Resistant DepressionMajor Depressive EpisodeMajor Depression+4 more

Estimated

~$10 – $1,125

Mark NiciuNCT04480918

Phase 3

A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of NBI-1065845 as Adjunctive Treatment in Subjects With Major Depressive Disorder (MDD)

The study will evaluate the efficacy of NBI-1065845 compared with placebo as an adjunctive treatment in participants with MDD on improving symptoms of depressi…

Major Depressive Disorder

Estimated

~$10 – $8,750

Neurocrine BiosciencesNCT06786624

Phase 2

Orexin Antagonism to Target Mechanisms of Suicide Risk: A Proof-of-Concept Clinical Trial

The goal of this proof-of-concept clinical trial is to evaluate the initial safety, feasibility, and tolerability of the orexin mixed antagonist suvorexant in …

Suicide RiskMajor Depressive Disorder (MDD)

Estimated

~$10 – $7,500

Marianne GoodmanNCT06854224

Observational

Maintaining the Acute Therapeutic Effect of rTMS in Treatment-Resistant Depression (Maitr-De)

Repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising intervention for treatment-resistant depression (TRD), yet substantial uncertain…

Major Depressive DisorderTreatment Resistant Depression

Estimated

~$10 – $6,250

University of California, San DiegoNCT06938841

Observational

Tracking the Dynamic Trajectory of Behavioral, Physiological, and Neurobiological Stress Responses in Female Adolescents at High and Low Familial Risk for Depression

Stress and a parental history of major depressive disorder (MDD) are among the strongest risk factors for future development of MDD. Studies have shown that ha…

Major Depressive Disorder

Estimated

~$10 – $6,250

Mclean HospitalNCT06816329

Phase 2

A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of SPN-821 as an Adjunctive Therapy in Adults With Major Depressive Disorder

This study will evaluate the efficacy and safety of SPN-821 in adults with major depressive disorder

Major Depressive Disorder (MDD)

Estimated

~$10 – $8,750

Supernus Pharmaceuticals, Inc.NCT07226661

Observational

Linking Affective Dynamics in Response to Daily Stress to Peripheral Vascular Function in Working Age Adults

The objective of this proposal is to determine whether heightened negative affective responsivity (NA-R) to daily stressors is related to blunted nitric oxide …

Major Depressive Disorder

Estimated

~$10 – $6,250

University of DelawareNCT06860724