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Clinical and Basic Investigations of Methylmalonic Acidemia (MMA) and Related Disorders
Methylmalonic acidemia (MMA), one of the most common inborn errors of organic acid metabolism, is heterogeneous in etiology and clinical manifestations. Affect…
Effects of Acute and Chronic Ketone Ester Consumption on Exercise Tolerance and Cardiac Function in Subjects With Diabetes
This study is being done to evaluate how a ketone ester (KE) supplement affects heart function and health in people with diabetes compared to a placebo supplem…
Personalized Responses to Dietary Composition Trial 3
The PREDICT 3 study will build on previous research in over 2,000 individuals to further refine machine learning models that predict individual responses to fo…
Prandial Metabolic Phenotype in Adults
Previous studies suggest that changes in metabolism due to the effects of aging might serve as a potential for therapeutic agents. The investigating lab develo…
Regulation of Endogenous Glucose Production by Central KATP Channels
Type 2 diabetes (T2D) affects the ability of the body to process glucose (sugar). Under fasting conditions, the liver is able to make sugar to maintain glucose…
The Effects of Natriuretic Peptide Augmentation on Cardiometabolic Health in Black Individuals (NAUTICAL)
Black individuals are more likely to have decreased insulin sensitivity which results in a high risk for the development of cardiometabolic disease. The reason…
Animal and Plant Proteins and Glucose Metabolism
The goal of this proposal is to determine the effect of a high protein diet in which the increase in protein intake is derived from different sources (animal v…
Studying Phenotypic Risks for Obesity and Underlying Traits in Young Infants: A Pilot Study
The purpose of this research study is to understand how infants metabolize different meals and to develop clinical tools which identify infants as having two d…
Does Vitamin C Increase the Body Heat Generated By The Nervous System?
The goals of this clinical trial are to determine whether or not vitamin C is able to: (1) increase the body heat generated by the sympathetic nervous system; …
A Phase I/IIa, Single Site, Open-Label, Ascending Dose Study to Evaluate the Safety and Efficacy of OPF-310 [Encapsulated Porcine Islet Cells for Xenotransplantation] in Subjects With Type 1 Diabetes Mellitus
This study is First In Human study for Encapsulated Porcine Islet Cells for Xenotransplantation (OPF-310). The purpose of this study to assess the safety, tole…
Evaluation of Biomarkers for Predicting Macronutrient Intake
The goal of this clinical trial is to establish the relationship between macronutrient food intake and the resulting blood and intersticial fluid (ISF )levels …
Atrial Natriuretic Peptide and Regulation of Cardiometabolic Health: A Genotype-Guided Human Physiological Study
Natriuretic Peptides (NP) are hormones produced by the heart, and they have a wide range of favorable metabolic benefits. Lower levels of these hormones are as…