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9 recruiting studies matching your filters

Syk Inhibition in MItigating Lung Allograft Rejection (SIMILAR): A Phase 1, Double-Blind, Randomized, Placebo-Controlled, Dose Escalation Trial to Evaluate the Safety and Tolerability of Fostamatinib in Lung Transplant Patients With Donor-Specific Antibodies.

Background: People who have lung transplants often survive 6 or 7 years. But some people develop donor-specific antibodies (DSA) after their transplants; anti…

Lung Transplantation

Estimated

~$10 – $5,625

National Heart, Lung, and Blood Institute (NHLBI)NCT06948097

Respiratory, Limb Muscle Properties, and Physical Performance in Adult Lung Transplant Recipients

The goal of this observational study is to evaluate respiratory and limb muscle properties in adults awaiting lung transplantation and determine how these meas…

Lung TransplantationEnd Stage Lung Disease

Estimated

~$10 – $750

University of FloridaNCT07747337

Clinical Risk Factors for Primary Graft Dysfunction

Primary graft dysfunction (PGD) is a severe lung complication that can occur in the days after lung transplant surgery. This study will analyze blood samples t…

Primary Graft DysfunctionLung Transplantation

Estimated

~$10 – $750

University of PennsylvaniaNCT00552357

Trifecta-Lung cfDNA-MMDx Study: Comparing the Dd-cfDNA Test to MMDx Microarray Test and Central HLA Antibody Test

Demonstrate the relationship between dd-cfDNA levels and HLA antibodies in blood transplant recipient and Demonstrate the Molecular Microscope® (MMDx) Diagnost…

Lung Transplantation

Estimated

~$10 – $750

University of AlbertaNCT05837663

Phase 2

A Randomized, Placebo-controlled Phase 2 Study to Demonstrate the Safety and Efficacy of the Addition of LAM-001 to Standard Immunosuppression Therapy for Chronic Lung Allograft Dysfunction (BOS).

The goal of this clinical trial is to learn about the safety and effectiveness of LAM-001 in patients who have developed bronchiolitis obliterans syndrome (BOS…

Bronchiolitis Obliterans SyndromeChronic Lung Allograft DysfunctionLung Transplantation

Estimated

~$10 – $7,500

Steven Hays, MDNCT06018766

Observational

Application of Lung Ultrasound Artefact Analysis for Exclusion of Acute Rejection in Asymptomatic Lung Transplant Recipients

This study is being done to study a safe and non-invasive way to diagnose lung rejection and infection.

Post-Lung Transplantation Bronchiectasis

Estimated

~$10 – $6,250

Mayo ClinicNCT04582279

Observational

Transplanting Lungs From Uncontrolled Donation After Circulatory Death: An Early Phase Clinical Trial

The study team developed an uncontrolled donation after circulatory death (uDCD) protocol that preserves lungs for just over 3 hours after death using positive…

Lung Transplantation

Estimated

~$10 – $7,500

NYU Langone HealthNCT06327945

Phase 2

A Randomized Trial of CCR5 Inhibition as a Complement to Lung Transplant Induction Immunosuppression

Lung transplant recipient survival lags other solid organ recipients, with the main early cause of death being primary graft dysfunction (PGD). PGD occurs in u…

Primary Graft DysfunctionLung TransplantationAcute Lung Injury(ALI)+1 more

Estimated

~$10 – $5,625

University of California, San FranciscoNCT06853223

Observational

Effect of Inspiratory Muscle Training on Physiological Function and Clinical Outcomes After Lung Transplant: A Randomized Controlled Trial

The purpose of this research is to study the effect of training the inspiratory muscles (i.e. the muscle that allow you to breath-in) on exercise capacity, qua…

Post-Lung Transplantation Bronchiectasis

Estimated

~$10 – $6,250

Mayo ClinicNCT04783155