The objective of this trial is to assess the effects of replacing foods high in refined carbohydrates, particularly added sugars, with avocado (isocaloric subs…

Overweight (BMI > 25)Obesity (BMI>30)Hs-CRP

~Estimated

~$10 – $7,500

Midwest Center for Metabolic and Cardiovascular ResearchNCT07566325

Phase 2

A Randomized-Controlled Trial of Semaglutide for Patients With Chronic Low Back Pain and Obesity

Low back pain is the leading cause of disability in the United States, and obesity is a major risk factor for its development. GLP-1 receptor agonists such as …

Lower Back PainObesity (BMI>30)Chronic Lower Back Pain+1 more

~Estimated

~$10 – $6,250

Washington University School of MedicineNCT07731256

Phase 1

Interplay of Central and Peripheral Vascular Effects of Insulin in Obesity

Determine the impact of obesity with insulin resistance on the neurovascular response to brain insulin stimulation.

Obesity (BMI>30)Insulin Resistance

~Estimated

~$10 – $6,250

University of Missouri-ColumbiaNCT07653464