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Evaluation of a Vibrational Guidewire System to Facilitate Crossing Coronary Artery Chronic Total Occlusions in Patients With Chronic Angina Refractory to Maximally Tolerated Guideline Directed Medical Therapy

The goal of this project is to provide an improvement in wire performance to expedite crossing difficult lesions in the coronary vasculature.

Chronic Total Occlusion of Coronary ArteryChronic Angina

Estimated

~$10 – $8,750

VasoStar, LLCNCT06193954

Observational

Understanding Defecation Patterns Using a Novel Device (Fecobionics) to Improve Treatment of Constipation

Chronic constipation (CC) is a common condition that affects up to 25% of the population in North America. It poses a major burden on the healthcare cost. The …

Constipation by Outlet Obstruction

Estimated

~$10 – $8,750

The California Medical Innovations Institute, Inc.NCT04903470

Observational

Breathing Low Oxygen to Enhance Spinal Stimulation Training and Functional Recovery in Persons With Chronic SCI: The BO2ST Trial

The purpose of this study is to determine how combining bouts of low oxygen, transcutaneous spinal cord stimulation, and walking training may improve walking f…

Spinal Cord Injuries

Estimated

~$10 – $6,250

Spaulding Rehabilitation HospitalNCT05563103

Phase 2

The Role of Inflammation in Cognitive Dysfunction in Acute Depression as Determined by Experimental Inhibition of Tumor Necrosis Factor-alpha Signaling in a Randomized Controlled Trial.

This study is a mechanistic randomized controlled trial that investigates whether inhibition of tumor necrosis factor signaling via intravenous infusion of inf…

Depressive Disorder, MajorInflammation

Estimated

~$10 – $6,250

Massachusetts General HospitalNCT06136546

Observational

Randomized, Controlled, Open-Label, Parallel Group, Multi-Center, Prospective Phase 4 Study Comparing the Efficacy of Transforming Powder Dressing to NPIAP Recommended Standard of Care Therapies in Stage 2, 3 and 4 Pressure Injuries

Pressure injuries, commonly known as pressure ulcers, affect over 2.5 million people in the United States. Pressure injuries are classified into four escalatin…

Pressure Ulcers Stage IIPressure Ulcers Stage IIIPressure Ulcer, Stage IV

Estimated

~$10 – $8,750

ULURU Inc.NCT05496296

POWERMOM, A Healthy Pregnancy Research Community

This study will take advantage of the open source framework of ResearchKit developed by Apple to bring research directly to participants. Using the ResearchKit…

Estimated

~$10 – $1,125

Scripps Translational Science InstituteNCT03085875

The Epidemiology and Pathophysiology of Kidney Disease in HFpEF With Obesity

This research study wants to learn about Chronic Kidney Disease (CKD) with Obesity, and Heart Failure with preserved Ejection Fraction (HFpEF) and better ways …

Chronic Kidney DiseaseHeart Failure With Preserved Ejection Fraction (HFPEF)Obesity (Disorder)

Estimated

~$10 – $750

University of Mississippi Medical CenterNCT07052539

Phase 3

Metformin BenefIts Lower Extremities With Intermittent Claudication (MOBILE_IC)

Peripheral arterial disease (PAD) affects over 20% of aged adults and is very common among Veterans due significant tobacco use. PAD is due to the progressive …

Intermittent Claudication

Estimated

~$10 – $5,625

VA Office of Research and DevelopmentNCT05132439

Observational

Noninferiority Evaluation of Human Milk Concentrating Device to Optimize Mother's Own Milk

This study is a randomized, non-inferiority clinical trial evaluating a human milk concentration (HMC) device in preterm infants. The trial compares outcomes i…

Preterm Infant HealthPremature Babies

Estimated

~$10 – $7,500

Mother's Milk is BestNCT07576972

A Multicenter Prospective Study Evaluating Outcomes of Endoscopic Eradication Therapy in Patients With Barrett's Esophagus Associated Neoplasia: The TREAT-BE (Treatment With Resection and Endoscopic Ablation Techniques for Barrett's Esophagus) Consortium

A prospective outcomes study in patients with and esophageal cancer (EAC) and Barrett's esophagus (BE) associated neoplasia being evaluated for endoscopic erad…

Barrett's EsophagusEsophageal Cancer

Estimated

~$10 – $750

University of Colorado, DenverNCT02634645

Phase 2

A Randomized Double-Blind Placebo-Controlled Phase II Multi-Center Study of Inflammation Modification of Canakinumab to Prevent Leukemic Progression of Clonal Cytopenias of Unknown Significance (CCUS): IMPACT Study

This phase II trial tests how well canakinumab works to prevent progression to cancer in patients with clonal cytopenias of unknown significance (CCUS). CCUS i…

Clonal Cytopenia of Undetermined Significance

Estimated

~$10 – $7,500

Uma BorateNCT05641831

Observational

Efficacy of Repeated Low-level Red-light Therapy in Myopia Control: a Single Arm Controlled Trial

Low-level red-light technology provides a new and innovative myopia control approach. This strategy enables relatively high energies of light to be delivered a…

Myopia

Estimated

~$10 – $5,625

University of California, San FranciscoNCT05606237